SUMF1 Activators
SUMF1 Activators are an array of chemical compounds that indirectly enhance the activity of SUMF1 through distinct signaling mechanisms. The activator Forskolin raises intracellular cAMP levels, which can lead to PKA activation. PKA, in turn, is capable of phosphorylating proteins that may stabilize SUMF1 or improve its interaction with substrates, thus enhancing its functional role in the post-translational modification of sulfatases. PMA, through PKC activation, could phosphorylate interacting partners of SUMF1, potentially increasing its catalytic efficiency. Similarly, Ionomycin, by boosting intracellular calcium levels, may indirectly activate kinases that upregulate SUMF1's sulfatase-modifying activity. Dibutyryl-cAMP, a synthetic cAMP analog, might enhance PKA activity and promote phosphorylation events that facilitate the functional engagement of SUMF1 in cellular processes.
Complementing these mechanisms, Sphingosine-1-phosphate, a signaling lipid, could initiate receptor-mediated pathways that support SUMF1's role in sulfatase maturation. EGCG, through kinase inhibition, may alleviate inhibitory phosphorylations, indirectly upregulating SUMF1 pathways. LY294002, a PI3K inhibitor, could alter AKT signaling, potentially enhancing SUMF1 activity by affecting its cellular localization or stability. Moreover, SB203580 and U0126, which inhibit p38 MAPK and MEK respectively, might remove inhibitory phosphorylations, indirectly facilitating SUMF1 activation. Resveratrol, by activating SIRT1, has the potential to deacetylate proteins and thus modify SUMF1 activity or stability. A23187, a calcium ionophore, and Staurosporine, a broad-spectrum kinase inhibitor, could selectively activate pathways or relieve specific kinase-mediated inhibition on SUMF1's associated processes, thus enhancing its functional activity in the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can indirectly enhance SUMF1 activity by cAMP-dependent protein kinase (PKA) mediated phosphorylation that can influence SUMF1's stability and interaction with substrates. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate proteins that interact with SUMF1, potentially increasing its catalytic efficiency in the sulfatase modification pathway. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin elevates intracellular calcium levels, which may indirectly activate calcium-dependent kinases that could enhance SUMF1's functional role in post-translational modification of sulfatases. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP acts as a membrane-permeable cAMP analog, mimicking the action of endogenous cAMP and potentially enhancing PKA activity, which could indirectly upregulate SUMF1 activity by phosphorylation mechanisms. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that activates sphingosine-1-phosphate receptors, which could lead to downstream signaling events that enhance the function of SUMF1 in sulfatase maturation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits a range of kinases, potentially reducing competitive inhibitory phosphorylations, thereby allowing pathways that favor SUMF1 activation to become more prominent. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that could alter downstream AKT signaling, which may indirectly enhance SUMF1 activity by modifying the cellular localization or stability of SUMF1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that could shift the signaling equilibrium, potentially removing inhibitory effects on SUMF1 and allowing enhanced activation of sulfatase modification processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which can deacetylate certain lysine residues on proteins potentially influencing SUMF1's activity or stability in the cell. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, which may activate calcium-dependent protein kinases, potentially enhancing the functional role of SUMF1. | ||||||