Stra8 Activators
Stra8 Activators are a category of chemical compounds that are recognized for their role in modulating the activity of the Stimulated by Retinoic Acid gene 8 (Stra8), a protein that is crucial in the process of meiosis. The gene that encodes the Stra8 protein is considered a key player in the initiation of meiotic cell division, which is an essential step in the maturation of germ cells. These activators interact with the regulatory elements of the Stra8 gene or its protein product, leading to an upregulation of its expression or function. As such, Stra8 activators are often the subject of intense study in cellular biology, particularly within the contexts of cell differentiation and development. The mechanisms by which these activators function are complex, involving intricate pathways of intracellular signaling and gene expression regulation.
The chemical structures of Stra8 activators can vary widely, but they share the common feature of being able to modulate the Stra8 pathway. This modulation occurs through a variety of mechanisms, including direct binding to the Stra8 protein, altering its conformation and thereby its activity, or by affecting the transcriptional machinery that governs the expression of the Stra8 gene. These activators may also function indirectly by influencing the cellular milieu or by interacting with other signaling molecules or cofactors that are involved in the regulation of Stra8. Research into the molecular details of Stra8 activators has provided insights into the fundamental processes of cell biology, such as the control of gene expression, signal transduction pathways, and the delicate orchestration of cellular differentiation and proliferation. The study of these compounds continues to be a dynamic field, with ongoing investigations into their diverse structures and mechanisms of action.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is a metabolite of vitamin A that regulates gene expression through retinoid receptors. In the context of germ cell development, retinoic acid is a known inducer of Stra8, leading to its activation and promotion of meiotic entry in spermatogonia and the initiation of meiosis in female germ cells. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, resulting in increased levels of cAMP, which is known to trigger signaling cascades that can lead to the activation of proteins like Stra8 by influencing cellular differentiation processes. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that directly stimulates cAMP-dependent pathways, potentially leading to the activation of Stra8 through the promotion of the differentiation of germ cells. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that changes the chromatin structure, thereby affecting gene expression. This compound might create a permissive environment for the expression of genes like Stra8 involved in cell differentiation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid, another histone deacetylase inhibitor, could similarly induce a conducive chromatin state for the expression and activation of Stra8 by facilitating gene transcription related to germ cell development. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can lead to hypomethylation of DNA and potentially activate genes such as Stra8 by reversing epigenetic silencing, hence promoting germ cell differentiation. | ||||||
Vinclozolin | 50471-44-8 | sc-251425 | 250 mg | $23.00 | 1 | |
Vinclozolin, an antiandrogenic compound, might indirectly promote Stra8 activation by disrupting androgen signaling, which can influence the hormonal regulation of germ cell development and thereby affect Stra8 activity. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole inhibits steroid biosynthesis and might indirectly lead to Stra8 activation by altering hormonal balances that regulate germ cell maturation and development, where Stra8 plays a crucial role. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a protein kinase C (PKC) activator that can modulate signaling pathways involved in cell differentiation, potentially leading to the activation of differentiation-related proteins such as Stra8. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3), which can lead to the activation of signaling pathways such as Wnt/beta-catenin that may indirectly activate Stra8 during processes like cellular differentiation in germ cells. | ||||||