Stra8 Inhibitors
Stra8 (Stimulated by retinoic acid gene 8) inhibitors comprise a chemical class designed to regulate the process of meiosis, particularly in germ cells where Stra8 is known to play a crucial role. These inhibitors work by interfering with the signaling pathways that induce the expression of the Stra8 gene, which is essential for the initiation of meiosis in both male and female germ cells. The precise biochemical mechanisms by which Stra8 inhibitors exert their effects involve the modulation of retinoic acid signaling, which is a key activator of Stra8 expression. By inhibiting the enzymes that synthesize retinoic acid or the receptors that mediate its action, Stra8 inhibitors can effectively suppress the transcriptional activation of the Stra8 gene, thereby hindering the progression of meiosis.
The significance of Stra8 in meiotic initiation makes its inhibitors particularly interesting from a developmental and cellular biology standpoint. These inhibitors can directly or indirectly affect the concentration of retinoic acid available in the cellular milieu, which, in turn, influences the Stra8 protein levels. Some inhibitors might target the aldehyde dehydrogenases responsible for the biosynthesis of retinoic acid, while others may bind to retinoic acid receptors, preventing their dimerization and subsequent transcriptional activity. This blockade of retinoic acid's action prevents the upregulation of Stra8 that is normally observed in response to retinoic acid signals. By controlling the availability or activity of retinoic acid, Stra8 inhibitors can serve as valuable tools for researchers studying gametogenesis and the intricate controls of cellular differentiation. The effect of these inhibitors underscores the importance of Stra8 in the precise orchestration of the steps leading from germ cell proliferation to the specialized process of forming gametes capable of undergoing fertilization.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor that promotes chromatin remodeling. Since Stra8 expression is initiated by retinoic acid signaling, which involves chromatin modification, Trichostatin A can indirectly inhibit Stra8 by maintaining a deacetylated state of histones, thereby preventing the transcriptional activation of Stra8. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $26.00 $77.00 $151.00 $303.00 | 1 | |
A nonsteroidal anti-inflammatory drug that also acts as a modulator of cellular retinoic acid-binding proteins. By altering the availability of retinoic acid, it can indirectly inhibit Stra8 expression, which is regulated by retinoic acid signaling. | ||||||
BMS 493 | 215030-90-3 | sc-361124 sc-361124A | 10 mg 50 mg | $450.00 $1400.00 | 7 | |
A pan-retinoic acid receptor inverse agonist that can inhibit the activation of retinoic acid receptors. Since Stra8 expression is dependent on retinoic acid receptor signaling, BMS-493 can indirectly suppress the expression of Stra8 by inhibiting this pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A phosphatidylinositol 3-kinase inhibitor that can impede the PI3K/AKT pathway, which is implicated in cell proliferation. This inhibition can indirectly affect the cell conditions necessary for Stra8 expression, as Stra8 is involved in meiotic initiation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor which impacts cell cycle and growth by inhibiting mTORC1. It can indirectly inhibit Stra8 expression by affecting the cellular conditions that are favorable for its expression during germ cell development. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
A gamma-secretase inhibitor which interferes with Notch signaling. Since Notch signaling is involved in cell fate decisions, DAPT can indirectly inhibit Stra8 by altering the differentiation state of cells that typically express Stra8. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
A selective inhibitor of the TGF-beta receptor which can modulate cellular differentiation. By inhibiting TGF-beta signaling, SB431542 may indirectly inhibit Stra8 by affecting germ cell development where Stra8 is normally expressed. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A selective inhibitor of MEK, which is part of the MAPK/ERK pathway. By suppressing this pathway, PD98059 can indirectly reduce the expression of genes like Stra8 which are regulated by signals transduced through MAPK/ERK. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
An aldosterone antagonist that also has the capacity to modulate retinoic acid signaling. Through this off-target effect, spironolactone may inhibit Stra8 indirectly by altering the availability or metabolism of retinoic acid that controls Stra8 expression. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
A form of vitamin B3 that acts as an inhibitor of sirtuins, a class of NAD+-dependent deacetylases. Since sirtuins can regulate gene expression through deacetylation, nicotinamide may indirectly inhibit Stra8 by affecting the epigenetic landscape and gene expression profile. | ||||||