Molecular structure of BMS 493, CAS Number: 215030-90-3
BMS 493 (CAS 215030-90-3)
See product citations (7)
Alternate Names:
4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(phenylethynyl)-2-naphthalenyl]ethenyl]-benzoic acid
Application:
BMS 493 is an inverse agonist of pan-retinoic acid receptor (pan-RAR)
CAS Number:
215030-90-3
Purity:
≥95%
Molecular Weight:
404.50
Molecular Formula:
C29H24O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BMS 493 is an inverse agonist of pan-retinoic acid receptor (pan-RAR). Retinoic acid receptors (RARs) are ligand-dependent transcription factors that control a number of physiological processes. RARs exert their functions by regulating gene networks controlling cell growth, differentiation, survival, and death. This compound may act to increase nuclear corepressor (NCoR) interaction with RARs.
BMS 493 (CAS 215030-90-3) References
- A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field. | Hochgreb, T., et al. 2003. Development. 130: 5363-74. PMID: 13129847
- Retinoic acid and the transcription factor MafB act together and differentially to regulate aggrecan and matrix metalloproteinase gene expression in neonatal chondrocytes. | Zhang, Y. and Ross, AC. 2013. J Cell Biochem. 114: 471-9. PMID: 22961837
- Design and synthesis of boron containing potential pan-RAR inverse agonists. | Das, BC., et al. 2012. Tetrahedron Lett. 53: 1316-1318. PMID: 23180890
- Triphenyl phosphate-induced developmental toxicity in zebrafish: potential role of the retinoic acid receptor. | Isales, GM., et al. 2015. Aquat Toxicol. 161: 221-30. PMID: 25725299
- Influence of retinoic acid on human gingival epithelial barriers. | Groeger, S., et al. 2016. J Periodontal Res. 51: 748-757. PMID: 26833138
- Application of Impermeable Barriers Combined with Candidate Factor Soaked Beads to Study Inductive Signals in the Chick. | Wilde, S. and Logan, MP. 2016. J Vis Exp.. PMID: 27911385
- Engineered Coiled-Coil Protein for Delivery of Inverse Agonist for Osteoarthritis. | Yin, L., et al. 2018. Biomacromolecules. 19: 1614-1624. PMID: 29601728
- BMS 493 Modulates Retinoic Acid-Induced Differentiation During Expansion of Human Hematopoietic Progenitor Cells for Islet Regeneration. | Elgamal, RM., et al. 2018. Stem Cells Dev. 27: 1062-1075. PMID: 29737242
- Anti-inflammatory effects of minocycline are mediated by retinoid signaling. | Clemens, V., et al. 2018. BMC Neurosci. 19: 58. PMID: 30241502
- Tie2 regulates endocardial sprouting and myocardial trabeculation. | Qu, X., et al. 2019. JCI Insight. 5: PMID: 31112136
- Retinoic Acid Signal Negatively Regulates Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells. | Wang, J., et al. 2020. Stem Cells Int. 2020: 5891783. PMID: 32676119
- Effect of retinoic acid signaling on Ripply3 expression and pharyngeal arch morphogenesis in mouse embryos. | Okubo, T., et al. 2021. Dev Dyn. 250: 1036-1050. PMID: 33452727
- Deciphering the role of retinoic acid in hepatic patterning and induction in the mouse. | Guertin, TM., et al. 2022. Dev Biol. 491: 31-42. PMID: 36028102
- Wnt7b/β-catenin signaling pathway mediated by retinoid acid involved in the transdifferentiation of primary fetal alveolar epithelial type II cells. | Ma, J., et al. 2022. Gen Physiol Biophys. 41: 559-567. PMID: 36454116
Inhibitor of:
GREB1L, HoxA5, Myotubularin (MTM, MTMR), RAR, RARα, RARα2, RARβ, Stra8, and TIG2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMS 493, 10 mg | sc-361124 | 10 mg | $450.00 | |||
BMS 493, 50 mg | sc-361124A | 50 mg | $1400.00 |