Stra8 Antibody (526CT11.1.5): sc-517364

Stra8 Antibody (526CT11.1.5) is a mouse monoclonal IgM antibody that detects Stra8 protein of mouse, rat, and human origin by western blotting (WB). Anti-Stra8 antibody (526CT11.1.5) is available as the non-conjugated format. Stra8 protein, also known as stimulated by retinoic acid gene 8, is a crucial 338 amino acid cytoplasmic protein that plays a significant role in the reproductive system, particularly in meiosis. Stra8 protein is specifically expressed in testis and embryonic ovaries, where Stra8 is essential for premeiotic DNA replication in both male and female germ cells. This replication is a prerequisite for proper transition into meiosis, and disruption in Stra8 function can lead to incomplete meiosis, resulting in premature chromosome condensation in spermatocytes. Human Stra8 gene is located on chromosome 7, a region containing over 1,000 genes implicated in various genetic disorders, including Osteogenesis imperfecta and Williams-Beuren syndrome. Understanding Stra8 protein function is vital, as Stra8 facilitates meiosis onset and ensures genetic material integrity during gamete formation, essential for fertility and genetic information propagation across generations.

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Stra8 Antibody (526CT11.1.5) References:

1. Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8.  |  Miyamoto, T., et al. 2002. J Assist Reprod Genet. 19: 531-5. PMID: 12489526
2. Retinoic acid regulates sex-specific timing of meiotic initiation in mice.  |  Koubova, J., et al. 2006. Proc Natl Acad Sci U S A. 103: 2474-9. PMID: 16461896
3. Expression of stimulated by retinoic acid gene 8 (Stra8) in spermatogenic cells induced by retinoic acid: an in vivo study in vitamin A-sufficient postnatal murine testes.  |  Zhou, Q., et al. 2008. Biol Reprod. 79: 35-42. PMID: 18322276
4. Expression profile of male germ cell-associated genes in mouse embryonic stem cell cultures treated with all-trans retinoic acid and testosterone.  |  Silva, C., et al. 2009. Mol Reprod Dev. 76: 11-21. PMID: 18425777
5. Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice.  |  Anderson, EL., et al. 2008. Proc Natl Acad Sci U S A. 105: 14976-80. PMID: 18799751
6. STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation.  |  Mark, M., et al. 2008. J Cell Sci. 121: 3233-42. PMID: 18799790
7. Cre recombinase activity specific to postnatal, premeiotic male germ cells in transgenic mice.  |  Sadate-Ngatchou, PI., et al. 2008. Genesis. 46: 738-42. PMID: 18850594
8. Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene.  |  Oulad-Abdelghani, M., et al. 1996. J Cell Biol. 135: 469-77. PMID: 8896602