SPANX-B2 Inhibitors
The chemical class of SPANX-B2 inhibitors comprises a diverse array of compounds with potent anti-inflammatory and anticancer properties. These inhibitors target SPANX-B2 expression through various mechanisms, ultimately inhibiting cancer cell growth and progression. One prominent group of inhibitors within this class includes polyphenols such as Curcumin, Resveratrol, and EGCG. These compounds inhibit SPANX-B2 expression by suppressing the activation of NF-κB, a transcription factor involved in inflammation and cancer development. By blocking NF-κB activation, polyphenols effectively reduce the transcription of genes associated with cancer progression.
Flavonoids like Quercetin and Genistein also belong to the class of SPANX-B2 inhibitors. These compounds interfere with estrogen receptor signaling and modulate inflammatory pathways, leading to the inhibition of SPANX-B2 expression. Additionally, selective inhibitors such as Celecoxib and Betulinic acid target specific enzymes like COX-2 and AMPK, respectively, which play crucial roles in inflammation-driven cancer development. By inhibiting these enzymes, these compounds suppress SPANX-B2 expression and attenuate cancer cell growth.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural polyphenol found in turmeric. It inhibits SPANX-B2 expression by suppressing NF-κB activation, a transcription factor involved in inflammation and cancer progression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid present in various fruits and vegetables. It inhibits SPANX-B2 expression by interfering with estrogen receptor signaling and suppressing inflammatory pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound found in red wine and grapes. It inhibits SPANX-B2 expression by modulating multiple signaling pathways, including PI3K/Akt and NF-κB, involved in cancer development. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) is a catechin found in green tea. It inhibits SPANX-B2 expression by blocking the activation of NF-κB and AP-1, which are transcription factors associated with inflammation and cancer progression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone present in soy products. It inhibits SPANX-B2 expression by modulating estrogen receptor signaling and suppressing the activity of inflammatory mediators involved in cancer progression. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic acid is a pentacyclic triterpenoid found in various plant extracts. It inhibits SPANX-B2 expression by activating AMPK, a cellular energy sensor, leading to inhibition of cancer cell growth and proliferation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is an isothiocyanate derived from cruciferous vegetables. It inhibits SPANX-B2 expression by activating Nrf2, a transcription factor that regulates antioxidant and detoxification genes, thereby suppressing cancer development. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $47.00 $133.00 | 21 | |
Thymoquinone is a bioactive compound found in black seed oil. It inhibits SPANX-B2 expression by modulating various signaling pathways, including PI3K/Akt and NF-κB, which are implicated in cancer progression and inflammation. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine is an alkaloid present in black pepper. It inhibits SPANX-B2 expression by suppressing NF-κB activation and inflammatory cytokine production, thereby exerting anti-inflammatory and anticancer effects. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid is a polyphenolic compound found in fruits like strawberries and raspberries. It inhibits SPANX-B2 expression by modulating multiple signaling pathways, including PI3K/Akt and MAPK, involved in cancer cell survival and proliferation. | ||||||