SODD Activators
SODD Activators, short for Suppressor of Death Domains Activators, represent a class of chemical compounds that play a significant role in cellular processes, particularly in regulating cell survival and apoptosis. These activators are designed to interact with a protein known as SODD, or Suppressor of Death Domains, which is an important mediator in the apoptosis signaling pathway. Apoptosis, often referred to as programmed cell death, is a crucial mechanism for maintaining tissue homeostasis and eliminating damaged or unwanted cells in multicellular organisms.
AtSODD Activators are characterized by their ability to bind to the SODD protein, thereby modulating its function. SODD itself is a protein adapter that can interact with other proteins involved in apoptosis, such as members of the tumor necrosis factor receptor (TNFR) superfamily. By binding to SODD, these activators can influence the downstream signaling pathways triggered by TNFR family members. This modulation can result in either the promotion or inhibition of apoptotic cell death, depending on the specific context and cellular conditions.SODD Activators have garnered attention in the field of cell biology and signal transduction due to their potential to fine-tune apoptosis-related processes. Their role in the intricate dance of cell survival and death highlights the complexity of cellular signaling pathways and underscores the importance of chemical tools like SODD Activators in unraveling the mysteries of cellular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate and thereby enhance the function of SODD, potentially influencing its role in inhibiting death domain-containing proteins like TNFR1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits multiple tyrosine kinases, leading to reduced competition for signaling pathways that SODD may regulate. This can enhance SODD activity in pathways that are negatively regulated by tyrosine kinases. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuins, particularly SIRT1. SIRT1 can deacetylate proteins involved in TNFR1 signaling, which may enhance SODD activity by maintaining TNFR1 in an inactive state. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator that could lead to the phosphorylation of proteins in the TNFR1 complex, potentially influencing the stability and function of SODD in inhibiting receptor oligomerization and activation. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine increases reactive oxygen species (ROS) levels, which may influence the redox state of cysteine residues on SODD and thereby modulate its activity in death receptor signaling. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine induces autophagy and can upregulate the expression of heat shock proteins, which may aid in the proper folding and function of SODD, enhancing its inhibitory role on TNFR1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAPK, which could shift the signaling equilibrium in favor of pathways that SODD regulates, indirectly enhancing its function in stabilizing death domain-containing receptors. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates Nrf2, leading to the transcriptional activation of genes involved in anti-oxidative stress responses. This could indirectly enhance SODD activity by maintaining an environment conducive to its stabilizing function on TNFR1. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Celastrol inhibits the NF-κB pathway, which is interconnected with TNFR1 signaling. By modulating NF-κB activity, Celastrol can indirectly enhance the function of SODD in preventing TNFR1 activation. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
Z-VAD-FMK is a broad-spectrum caspase inhibitor. By inhibiting downstream effectors of death receptor pathways, it may enhance the effectiveness of SODD's role in inhibiting the activation of these pathways. | ||||||