SMRT/SMRTe Activators
SMRT/SMRTe activators belong to a class of chemical compounds designed to selectively target and modulate the activity of the silencing mediator of retinoic acid and thyroid hormone receptors (SMRT) and its related protein, SMRTe (SMRT family with ETO). These proteins are transcriptional corepressors that play a crucial role in the regulation of gene expression. SMRT and SMRTe are involved in transcriptional repression by recruiting histone deacetylases (HDACs) and other chromatin-modifying complexes to specific gene promoters. They act as transcriptional "brakes," inhibiting the transcriptional machinery from accessing and transcribing target genes.
Activation of SMRT and SMRTe by specific chemical compounds enhance their repressive functions, leading to the suppression of gene expression. These activators are designed to promote the recruitment of these corepressors to their target genes, thereby facilitating the repression of transcription and influencing various cellular processes. By modulating the activity of SMRT and SMRTe, researchers can gain insights into the complex regulatory networks that govern gene expression, chromatin remodeling, and cellular differentiation. These compounds serve as valuable tools for investigating the roles of SMRT and SMRTe in various cellular contexts and uncovering their contributions to normal cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may influence SMRT expression by modulating gene transcription through retinoic acid receptors, which could affect the co-repressor complex involving SMRT. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol could potentially enhance SMRT expression due to its role in regulating gene expression through the vitamin D receptor, which interacts with co-repressors like SMRT. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, might induce SMRT expression by altering chromatin structure and gene expression, potentially affecting the recruitment of co-repressor complexes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine may upregulate SMRT expression by inhibiting DNA methyltransferases, leading to changes in DNA methylation and gene expression patterns, including genes involved in transcription repression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin might influence SMRT expression by increasing intracellular cAMP levels, which can modulate various signaling pathways and potentially affect transcription regulation mechanisms. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA could potentially upregulate SMRT expression by activating protein kinase C (PKC), influencing signaling pathways that regulate gene expression, including transcription repressors. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone may affect SMRT expression through glucocorticoid receptor-mediated signaling, which is involved in the regulation of gene expression and may influence co-repressor dynamics. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane might modulate SMRT expression by affecting antioxidant response elements in the genome, which can have downstream effects on gene expression regulation, including transcription repression. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide could potentially enhance SMRT expression through its role in modulating NAD+ metabolism and sirtuin activity, which are linked to chromatin remodeling and gene regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin might influence SMRT expression by its anti-inflammatory and antioxidant properties, which can affect cellular signaling pathways and gene expression, including transcription repressors. | ||||||