Smooth muscle cells Activators
Functional SR Marker Activators are a class of compounds that indirectly enhance the functional activity of the Junctional SR Marker protein through various mechanisms affecting calcium dynamics within cells. Phosphatidylinositol 4,5-bisphosphate plays a crucial role as a precursor to IP3, facilitating the release of calcium and thus supporting the Junctional SR Marker's role in calcium storage and signaling. Similarly, compounds like Ryanodine and Caffeine target ryanodine receptors, modulating calcium release which is a key aspect of the function of the Junctional SR Marker. Dantrolene, by inhibiting these receptors, may indirectly cause an upregulation of Junctional SR Marker activity to counterbalance disruptions in calcium flow. Compounds such as 2-APB, Thapsigargin, A23187, and Cyclopiazonic Acid also contribute to the elevation of cytosolic calcium levels, which is likely to enhance the Junctional SR Marker activity as it compensates for altered calcium dynamics, highlighting its integral role in calcium regulation within the sarcoplasmic reticulum.
The functional activity of the Junctional SR Marker is also influenced by the action of ML-9, BTP2, Tetracaine, and Xestospongin C, which modulate calcium channels and IP3 receptors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine binds to ryanodine receptors, affecting calcium release from the sarcoplasmic reticulum. The increase in calcium signaling could indirectly enhance the functional activity of Junctional SR Marker in regulating calcium homeostasis. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine acts as a ryanodine receptor modulator, potentially increasing calcium release and thereby enhancing the role of Junctional SR Marker in calcium signaling within muscle cells. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene interacts with ryanodine receptors to inhibit calcium release, which can lead to a compensatory upregulation of Junctional SR Marker activity to maintain calcium balance. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB affects store-operated calcium entry by modulating the activity of IP3 receptors, which could increase the demand on Junctional SR Marker for calcium storage and signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to increased cytosolic calcium levels that may enhance the functional activity of Junctional SR Marker in response to altered calcium dynamics. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium concentration, potentially promoting the activity of Junctional SR Marker due to elevated calcium signaling requirements. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic Acid is an inhibitor of the SERCA pump, which would increase cytosolic calcium and could enhance the functional role of Junctional SR Marker in calcium regulation. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
ML-9 is a kinase inhibitor that can affect calcium channel phosphorylation states, potentially impacting Junctional SR Marker function by modulating calcium influx. | ||||||
CRAC Channel Inhibitor, BTP2 | 223499-30-7 | sc-221441 | 5 mg | $189.00 | 9 | |
BTP2 is an inhibitor of store-operated calcium entry channels, which may lead to an increased role for Junctional SR Marker in adjusting to changes in intracellular calcium levels. | ||||||
Tetracaine | 94-24-6 | sc-255645 sc-255645A sc-255645B sc-255645C sc-255645D sc-255645E | 5 g 25 g 100 g 500 g 1 kg 5 kg | $66.00 $309.00 $500.00 $1000.00 $1503.00 $5000.00 | ||
Tetracaine blocks voltage-gated calcium channels, which may indirectly necessitate enhanced Junctional SR Marker activity to regulate calcium homeostasis. | ||||||