Molecular structure of CRAC Channel Inhibitor, BTP2, CAS Number: 223499-30-7
CRAC Channel Inhibitor, BTP2 (CAS 223499-30-7)
See product citations (9)
Alternate Names:
YM-58483; YM58483; YM 58483
Application:
CRAC Channel Inhibitor, BTP2 is a cell-permeable analog of BTP
CAS Number:
223499-30-7
Purity:
≥98%
Molecular Weight:
421.32
Molecular Formula:
C15H9F6N5OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CRAC Channel Inhibitor, BTP2 is a cell-permeable analog of 3,5-bis(trifluoromethyl)pyrazole (BTP) which specifically inhibits CRAC-mediated calcium influx in T-cells with an IC50 about 10 nM and displays ~31-fold greater selectivity over VOC. CRAC Channel Inhibitor, BTP2 blocks the calcium-induced activation and translocation of nuclear factor of activated T-cells (NFAT). It does not affect the activation of NF-kappaB and AP-1. It potently inhibits cytokine production (IC50 = 1.7 muM for IL-2) and PBMC proliferation (IC50=190 nM).
CRAC Channel Inhibitor, BTP2 (CAS 223499-30-7) References
- Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2. | Zitt, C., et al. 2004. J Biol Chem. 279: 12427-37. PMID: 14718545
- Basiliolides, a class of tetracyclic C19 dilactones from Thapsia garganica, release Ca(2+) from the endoplasmic reticulum and regulate the activity of the transcription factors nuclear factor of activated T cells, nuclear factor-kappaB, and activator protein 1 in T lymphocytes. | Navarrete, C., et al. 2006. J Pharmacol Exp Ther. 319: 422-30. PMID: 16840645
- YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models. | Yoshino, T., et al. 2007. Eur J Pharmacol. 560: 225-33. PMID: 17307161
- The neurotransmitter GABA is a potent inhibitor of the stromal cell-derived factor-1alpha induced migration of adult CD133+ hematopoietic stem and progenitor cells. | Seidel, J., et al. 2007. Stem Cells Dev. 16: 827-36. PMID: 17999603
- STIM1 and STIM2-mediated Ca(2+) influx regulates antitumour immunity by CD8(+) T cells. | Weidinger, C., et al. 2013. EMBO Mol Med. 5: 1311-21. PMID: 23922331
- Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells. | Somasundaram, A., et al. 2014. J Neurosci. 34: 9107-23. PMID: 24990931
- Store-Operated Ca2+ Release-Activated Ca2+ Channels Regulate PAR2-Activated Ca2+ Signaling and Cytokine Production in Airway Epithelial Cells. | Jairaman, A., et al. 2015. J Immunol. 195: 2122-33. PMID: 26238490
- Suppression of arthritis-induced bone erosion by a CRAC channel antagonist. | Blair, HC., et al. 2016. RMD Open. 2: e000093. PMID: 26819750
- Allergens stimulate store-operated calcium entry and cytokine production in airway epithelial cells. | Jairaman, A., et al. 2016. Sci Rep. 6: 32311. PMID: 27604412
- Susceptibility of epithelial tumour cell lines to hyperthermia. | Li, ZX., et al. 2018. Eur J Dermatol. 28: 606-612. PMID: 30530432
- CRAC channel regulation of innate immune cells in health and disease. | Clemens, RA. and Lowell, CA. 2019. Cell Calcium. 78: 56-65. PMID: 30641250
- Protease-activated receptor 2 activates CRAC-mediated Ca2+ influx to cause prostate smooth muscle contraction. | Paul, M., et al. 2019. FASEB Bioadv. 1: 255-264. PMID: 31198907
- Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease. | Letizia, M., et al. 2022. EMBO Mol Med. 14: e15687. PMID: 35919953
- Targeting CRAC channels in inflammatory bowel disease. | Kappel, S. and Peinelt, C. 2022. EMBO Mol Med. 14: e16489. PMID: 35969215
Inhibitor of:
BSPII, C10orf63, copine 6, CRTAC1, Eapa2, GRP, NFAT5, Orai2, Orai3, PIRT, PMR1, RIC-8B, Stim1, Stim2, TMEM110, TPCN2, TRAPPC8, and TRPC4AP.Activator of:
ALG2, CatSperδ, Junctional SR Marker, Junctophilin-1, MBLAC1, N-type Ca++ CP α1B, Orai1, Plb2, Smooth muscle cells, TMEM38B, and Trav3d-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRAC Channel Inhibitor, BTP2, 5 mg | sc-221441 | 5 mg | $189.00 |