Molecular structure of ML-9, CAS Number: 105637-50-1
ML-9 (CAS 105637-50-1)
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Alternate Names:
1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine HCl;1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-1H-1,4-diazepine, monohydrochloride
Application:
ML-9 is a selective inhibitor of MYLK, CaMK, PKB Kinase, PKA, and Stim1
CAS Number:
105637-50-1
Purity:
≥98%
Molecular Weight:
361.29
Molecular Formula:
C15H17N2O2SCl•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ML-9 is a selective inhibitor of MYLK and CaMK that acts by delaying MYLK phosphorylation through binding at or near the ATP binding site. This naphthalenesulfonamide derivative may act to inhibit insulin-stimulated 2-deoxyglucose transport (IC50 = 27 muM), PP-1 activation in adipocytes, PKA, Akt1 (PKB) and Rsk (S6 kinase). ML-9 was also observed to disrupt microfilament bundles with accompanying decrease in P32 incorporation in rat astrocytes. Carbachol (sc-202092) illicited cationic currents were inhibited with ML-9 (IC50 = 7.8 muM) in HEK293 cells. ML-9 has also demonstrated to inhibit natural killer cell lytic acitivity by regulating microfilament contraction as well as catecholamine secretion in intact and permeabilized chromaffin cells. In addition, agonist-induced Ca2+ entry into endothelial cells was completely abolished in the presence of ML-9. Shown to act as an inhibitor of Stim1, PKC and ERK.
ML-9 (CAS 105637-50-1) References
- PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes. | Smith, U., et al. 2000. Biochem Biophys Res Commun. 268: 315-20. PMID: 10679201
- ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis. | Ito, S., et al. 2004. Eur J Pharmacol. 486: 325-33. PMID: 14985055
- Myosin light chain kinase-independent inhibition by ML-9 of murine TRPC6 channels expressed in HEK293 cells. | Shi, J., et al. 2007. Br J Pharmacol. 152: 122-31. PMID: 17603544
- Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death. | Kondratskyi, A., et al. 2014. Cell Death Dis. 5: e1193. PMID: 24763050
- Inhibition of natural killer cell-mediated cytotoxicity by ML-9, a selective inhibitor of myosin light chain kinase. | Ito, M., et al. 1989. Int J Immunopharmacol. 11: 185-90. PMID: 2703279
- Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. | Saitoh, M., et al. 1987. J Biol Chem. 262: 7796-801. PMID: 3108259
- ML-9 inhibits the vascular contraction via the inhibition of myosin light chain phosphorylation. | Ishikawa, T., et al. 1988. Mol Pharmacol. 33: 598-603. PMID: 3380076
- The alkalinizing, lysosomotropic agent ML-9 induces a pH-dependent depletion of ER Ca2+ stores in cellulo. | Kerkhofs, M., et al. 2022. Biochim Biophys Acta Mol Cell Res. 1869: 119308. PMID: 35710019
- The modulatory role of myosin light chain phosphorylation in human platelet activation. | Saitoh, M., et al. 1986. Biochem Biophys Res Commun. 140: 280-7. PMID: 3778449
- Effects of ML-9 on insulin stimulation of glucose transport in 3T3-L1 adipocytes. | Inoue, G., et al. 1993. J Biol Chem. 268: 5272-8. PMID: 7680348
- Stimulation of protein phosphatase-1 activity by insulin in rat adipocytes. Evaluation of the role of mitogen-activated protein kinase pathway. | Begum, N. 1995. J Biol Chem. 270: 709-14. PMID: 7822300
- Naphthalenesulfonamide derivatives ML9 and W7 inhibit catecholamine secretion in intact and permeabilized chromaffin cells. | Reig, JA., et al. 1993. Neurochem Res. 18: 317-23. PMID: 8479600
- Roles of inhibitors of myosin light chain kinase and tyrosine kinase on cation influx in agonist-stimulated endothelial cells. | Takahashi, R., et al. 1997. Biochem Biophys Res Commun. 235: 657-62. PMID: 9207215
Inhibitor of:
γ Enolase, 6330403A02Rik, Akt1, Amisyn, Anthrax LF, ANXA2R, C2CD4D, Caldesmon, CALHM3, Calponin 1, CALR3, CaMK, cAMP-GEFII, CAPS2, CHERP, CIB2, Claudin (CLDN), claudin-2, copine 6, Cypher, DANGER, EFR3B, EG667094, Enkurin, ERK, granuphilin, HSPC300, ICA1L, ITPRIPL2, Junctophilin-4, KIAA0953, LIN-2, LRRTM2, LRRTM4, MCTP1, MCTP2, Mg29, MLC, MLCKSK, MRLC2, MYH11, MYH13, MYH2, MYH3, MYH4, MYH8, MYH9, MYL10, MYL3, MYL6, MYL6B, MYL9, Mylc2b, MYLK, MYLPF, MyoD, Myosin, Myosin Ib, Myosin Ie, Myosin IIIa, Myosin IIIb, Myosin Va, Myosin VIIB, Myosin XVI, Myosin-neonatal, Myosin-XVA, MYPT1, neuroligin X, Neuropeptide S, NKG7, Olfr544, Olfr545, Orai2, Orai3, OTTMUSG00000018259, OTTMUSG00000018260, pantophysin, PATL2, PIPK I α, PKA, PKC, PLEKHM1, RIM-BP3, Rim3, Rsk, SCAMP3, SCRN3, SEC24A, Sec24B, Ser/Thr Protein Kinase, shootin1, STARS, Stim1, Stim2, SYAP1, SYCE3, Synaptotagmin V, Synaptotagmin X, Synaptotagmin XI, Synaptotagmin XV, Synaptotagmin XVI, Synaptotagmin XVII, TGN38A, TMCO1, TMCO5, TMEM101, TMEM110, TMEM170, TMEM199, TMEM203, TMEM24, TMEM38A, TMEM66, Tropomyosin, Troponin I-FS, UNC-79, V-ATPase C2, Vacuolar ATPase (V-ATPase; ATP6), VAT1, Vmn1r224, YIF1B, and ZFR.Activator of:
calsequestrin 1, CD39L3, CHMP7, CLRN2, ENSMUSG00000056133, Junctophilin-3, KIF1C, Leiomodin 2, Moesin, Myosin X, NEURL4, Orai1, S-100A10, Smooth muscle cells, TMEM38B, and VPS25.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ML-9, 10 mg | sc-200519 | 10 mg | $110.00 | |||
ML-9, 50 mg | sc-200519A | 50 mg | $440.00 | |||
ML-9, 100 mg | sc-200519B | 100 mg | $660.00 | |||
ML-9, 250 mg | sc-200519C | 250 mg | $1200.00 |