Smooth muscle cells Inhibitors
Smooth Muscle Cell inhibitors are a set of chemical compounds that decrease the functional activity of smooth muscle cells. These inhibitors act through various cellular and biochemical pathways, including phosphodiesterase inhibition, nitric oxide donation, calcium channel blockade, β1 receptor blockade, Rho-kinase inhibition, and myosin II inhibition. Phosphodiesterase inhibitors like Papaverine, Tadalafil, and Sildenafil increase intracellular cAMP and cGMP levels, leading to the relaxation of smooth muscle cells. Nitric oxide donors such as Sodium Nitroprusside, Nitroglycerin and Isosorbide Dinitrate activate guanylate cyclase to increase cGMP production, also resulting in smooth muscle cell relaxation.
Calcium channel blockers such as Verapamil, Diltiazem, and Nifedipine decrease intracellular calcium levels, which inhibits the contractile mechanism of smooth muscle cells. Atenolol, a selective β1 receptor blocker, inhibits the release of renin, which reduces the production of angiotensin II and aldosterone, leading to decreased contractile activity of smooth muscle cells. Y-27632 is a Rho-kinase inhibitor that inhibits the RhoA/Rho-kinase pathway, leading to decreased phosphorylation of myosin light chain, an essential component of the contractile machinery of smooth muscle cells. Lastly, Blebbistatin is a myosin II inhibitor that inhibits the ATPase activity of myosin II, leading to decreased contraction of smooth muscle cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Papaverine | 58-74-2 | sc-279951 sc-279951A sc-279951B | 10 mg 50 mg 100 mg | $153.00 $265.00 $459.00 | ||
Papaverine is a phosphodiesterase inhibitor that increases intracellular cAMP and cGMP levels, leading to the inhibition of the contractile activity of smooth muscle cells. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Sodium Nitroprusside is a nitric oxide donor that activates guanylate cyclase, increasing cGMP production, which can lead to the relaxation of smooth muscle cells. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is an L-type calcium channel blocker and its action can decrease intracellular calcium levels in smooth muscle cells, inhibiting their contractile mechanism. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem is another L-type calcium channel blocker that decreases intracellular calcium levels, leading to the inhibition of the contractile activity of smooth muscle cells. | ||||||
(RS)-Atenolol | 29122-68-7 | sc-204895 sc-204895A | 1 g 10 g | $79.00 $416.00 | 1 | |
Atenolol is a selective β1 receptor blocker that can inhibit the release of renin, reducing the production of angiotensin II and aldosterone, decreasing the contractile activity of smooth muscle cells. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a Rho-kinase inhibitor that can inhibit the RhoA/Rho-kinase pathway, leading to decreased phosphorylation of myosin light chain and inhibition of the contractile activity of smooth muscle cells. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin is a myosin II inhibitor that can inhibit the ATPase activity of myosin II, leading to decreased contraction of smooth muscle cells. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is an L-type calcium channel blocker that decreases intracellular calcium levels, inhibiting the contractile activity of smooth muscle cells. | ||||||
Tadalafil | 171596-29-5 | sc-208412 | 50 mg | $180.00 | 13 | |
Tadalafil is a phosphodiesterase-5 inhibitor that increases intracellular cGMP levels, leading to the relaxation of smooth muscle cells. | ||||||