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2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3.
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See how others have used 2-APB. Click on the entry to view the PubMed entry .
PMID: # 31001087 Cabrera Zapata, LE.|Bollo, M.|Cambiasso, MJ.| et al. 2019. Front Cell Neurosci. 13: 122.
PMID: # 29175331 Fujita, T. et al. 2017. Biochemical and biophysical research communications.
PMID: # 27733612 Bellocchio, L. et al. 2016. J. Neurosci. 36: 10611-10624.
PMID: # 26631534 Zhong, W. et al. 2016. Neuropharmacology. 103: 195-210.
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PMID: # 26690982 Kondo, K. et al. 2015. PLoS ONE. 10: e0144803.
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PMID: # 25121483 Zhong, W. et al. 2014. PLoS ONE. 9: e104718.
PMID: # 23458684 Masumoto, K. et al. 2013. Biochim. Biophys. Acta. 1830: 3382-90.
PMID: # 24048853 DeMaria, S. et al. 2013. J. Neurosci. 33: 15235-47.
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