Molecular structure of 2-APB, CAS Number: 524-95-8
2-APB (CAS 524-95-8)
See product citations (37)
Alternate Names:
2-Aminoethyl diphenylborinate
Application:
2-APB is a TRP activator that also blocks IP3R
CAS Number:
524-95-8
Purity:
≥98%
Molecular Weight:
225.09
Molecular Formula:
C14H16BNO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3.
2-APB (CAS 524-95-8) References
- 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. | Hu, HZ., et al. 2004. J Biol Chem. 279: 35741-8. PMID: 15194687
- Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. | Xu, SZ., et al. 2005. Br J Pharmacol. 145: 405-14. PMID: 15806115
- 2-APB induces instability in rat left atrial mechanical activity. | Wolkowicz, PE., et al. 2007. J Cardiovasc Pharmacol. 49: 325-35. PMID: 17513952
- 2-Aminoethoxydiphenyl-borate (2-APB) increases excitability in pyramidal neurons. | Hagenston, AM., et al. 2009. Cell Calcium. 45: 310-7. PMID: 19100621
- 2-APB and capsazepine-induced Ca2+ influx stimulates clathrin-dependent endocytosis in alveolar epithelial cells. | Usmani, SM., et al. 2010. Cell Physiol Biochem. 25: 91-102. PMID: 20054148
- Caffeine and 2-Aminoethoxydiphenyl Borate (2-APB) Have Different Ability to Inhibit Intracellular Calcium Mobilization in Pancreatic Acinar Cell. | Choi, KJ., et al. 2010. Korean J Physiol Pharmacol. 14: 105-11. PMID: 20473382
- 2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm. | Lefièvre, L., et al. 2012. Biochem J. 448: 189-200. PMID: 22943284
- 2-Aminoethyl diphenylborinate (2-APB) analogues: regulation of Ca2+ signaling. | Ozaki, S., et al. 2013. Biochem Biophys Res Commun. 441: 286-90. PMID: 24036266
- Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12. | Takahashi, K., et al. 2014. Exp Cell Res. 323: 337-45. PMID: 24630903
- Selective potentiation of 2-APB-induced activation of TRPV1-3 channels by acid. | Gao, L., et al. 2016. Sci Rep. 6: 20791. PMID: 26876731
- Orai3 channel is the 2-APB-induced endoplasmic reticulum calcium leak. | Leon-Aparicio, D., et al. 2017. Cell Calcium. 65: 91-101. PMID: 28179072
- Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells. | Schild, A., et al. 2020. Int J Mol Sci. 21: PMID: 32764353
- 2-Aminoethyl diphenylborinate inhibits bleomycin-induced skin and pulmonary fibrosis via interrupting intracellular Ca2+ regulation. | Hsu, WL., et al. 2021. J Dermatol Sci. 103: 101-108. PMID: 34315630
Inhibitor of:
β-defensin 46, 1700067K01Rik, 1700067P10Rik, 1700069P05Rik, 1700071A11Rik, 1700071K01Rik, 1700072E05Rik, 1700072O05Rik, 1700074I03Rik, 1700074P13Rik, 1700080E11Rik, 1700080G18Rik, 1700080N15Rik, 1700080O16Rik, 1700081L11Rik, 1700084C01Rik, 1700084D21Rik, 1700084E18Rik, 1700085B13Rik, 1700086D15Rik, 1700086L19Rik, 1700088E04Rik, 1700091H14Rik, 1700092M07Rik, 1810011H11Rik, 2610021K21Rik, 4922505G16Rik, 4930408G06Rik, 4931407G18Rik, 4933412E24Rik, 5730419I09Rik, 6430628N08Rik, 6720456H20Rik, 9130409J20Rik, adseverin, AHCYL2, ANKRD21, ANKRD55, ANKS3, Annexin VIII, APBA2BP, Ataxin-10, ATF-6α, ATP9B, BAP29, BC024139, Bestrophin-3, BSPII, C10orf63, C17orf57, C1orf201, C22orf42, C2CD4D, C3orf25, C6orf105, CAB39L, CaBP7, CaBP8, cadherin-20, Calbindin D9K, Calgizzarin, CALHM1, CALHM2, Calmegin, CALR4, CaM V, CASKIN1, CASPR3, CAT-1, CatSperβ, CatSperγ2, CBARA1 (MICU1), CCDC102A, CCDC109A, CCDC24, CCDC32, CCDC90A, Centrin, Centrin-3, Cerebellin 4, CGREF1, CHERP, connexin (GJA; gap junction), connexin 23, connexin 25, connexin 26, connexin 29, connexin 30, connexin 32, connexin 33, connexin 36, connexin 39, connexin 40.1, connexin 45, connexin 46, connexin 47, connexin 59, copine 3, copine 6, copine 7, copine 9, CRISP-4, CUTA, Cypt15, DANGER, DJBP, DOC2A, DPY19L2, E230019M04Rik, E6BP, EF-CBP2, EG238829, EG434008, EG625591, EG631584, EG666504, EG667094, Enkurin, FAM129B, FAM26A, FATE1, FIT2, FTSJD2, G630016D24Rik, Gm5849, GPR144, HCN1, HRC, HVCN1, IGSF3, ILVBL, INPP1, IP3KA, IP3KB, IP3R, IP3R-III, ITPRIPL1, ITPRIPL2, Junctional SR Marker, Junctophilin-4, KRTAP7-1, KVβ.2, LAIR-2, LIN-2, LOC100041456, LOC391356, LOC727972, LRRC45, LRRC54, LTRPC7, M6B, MAVS, MCTP1, MCTP2, Mg29, MP19, MPV17, MRS2L, mucolipin 3, neurexin I, neurocalcin δ, neuroligin 2, NFATc2IP, NHLRC4, NID67, NIPA2, Nir1, NOL7, NRBP, nucleobindin, OCML, Olfr1016, Olfr1038, Olfr1046, Olfr1090, Olfr110, Olfr1101, Olfr1107, Olfr370, Olfr381, Olfr455, Olfr457, Olfr46, Olfr492, Olfr605, Olfr713, Olfr715, Olfr720, Olfr734, Olfr76, Olfr761, Olfr763, Olfr788, Olfr828, Olfr837, Olfr851, Olfr900, Olfr936, Olr1014, OR1J1, OR1L8, OR52E5, Orai1, Orai2, Otoconin 90, OTOP3, OTRPC4, OTTMUSG00000018259, OTTMUSG00000018260, PAL, Palmdelphin, parvalbumin α, PCDHA6, PCDHA8, PCDHA9, PCDHB14, PCDHB6, PCDHBPcdhb22, PCNXL2, PIRT, PLAC1, PLAC8L1, PLC ε, PLC γ1, PLC ζ, PLCδ1, PLSCR1, PMCA2, PMCA3, PMCA4, PMCA4b, PMR1, PNMA6E, Polycystin-1L2, Polycystin-1L3, Polycystin-2, Polycystin-L2, PRAM-1, Protamine 2, PTPIP51, PYGM, RASEF, Recoverin, REEP2, reticulocalbin-3, Reticulum Cell, RNase L, RyR-2, S-100A3, S-100P, SAMD14, Shank 2, Silg111, SLC41A1, SLC41A3, SNAP 23, SNT-2, SOLO, SPCA1, SPCA2, Stim1, Stim2, STOML3, Synaptotagmin X, syncytin, Syntaxin 1B, SYP, TANC2, TAPP2, TM4SF19, TMCO1, TMCO5, TMCO6, TMCO7, TMEM101, TMEM102, TMEM110, TMEM12, TMEM120B, TMEM141, TMEM143, TMEM150A, TMEM165, TMEM16K, TMEM171, TMEM184B, TMEM188, TMEM19, TMEM199, TMEM200A, TMEM201, TMEM24, TMEM35, TMEM53, TMEM63A, TMEM66, TMEM80, TMEM86A, TMEM86B, TMIE, TMTC2, TMTC3, Torsin4A, TPCN2, TRAPPC8, Triadin, Trp3, Trp4, Trp5, Trp6, Trp7, TRPC3, TRPC4AP, TRPV5, TRPV6, TSPAN2, V1RG4, V1RG5, V1RH2, V1RH4, VCAC3, VILIP-2, Vmn1r100, Vmn1r127, Vmn1r143, Vmn1r158, Vmn1r159, Vmn1r161, Vmn1r163, Vmn2r102, Vmn2r13, Vmn2r14, Vmn2r24, Vmn2r8, XKR5, Zap3, and ZPBP2.Activator of:
1700001N15Rik, AHCYL1, ALG2, BAP31, BY080835, C14orf1_0610007P14Rik, C16orf78, C16orf82, C17orf57, C9orf38, CaBP2, CaBP4, CaBP5, CALM, CALML5, calmodulin, Calnexin, CALR3, Calretinin, calsequestrin 1, Calumenin, CaM V, CaMKIδ, CaMKIIN2, CANT1, CatSperδ, CCDC40, CD3-δ, CHP2, CIB, CLEC-6, CLRN2, connexin 39, copine 2, CRLR, cryptdin 5, Cryptosporidium parvum, DCAF15, DEPDC7, DGCR14, DOC2B, DOCK 8, E030010A14Rik, EF-CAB2, EF-CAB8, EF-HB, EG229862, EG620736, Egr-2, ELKS, Enkurin, FAM127B, FBL18, FLJ10081, FLJ30851, FLJ46082, Gm5849, Grancalcin, GRF-1, HCCR-1, HPV18 E7, IP3KC, IP3R-I, iPLA2γ, IPMK, IQCJ, ITPK1, Jaw1, KChIP4, KIAA0494, Lamin B2, LOC221710, LOC285423, LOC85449, LRP4, LSmD1, Ly-49Q, LZIP, Mitsugumin23, MS4A14, MS4A4C, MT-MMP-3, Mucin 20, Muted, NIPSNAP2, Nox5, NUDT6, OBSL1, Olfr51, Olfr510, Olfr706, Olfr90, Olfr900, Olfr901, Orai3, Ost1, OTTMUSG00000005723, OTTMUSG00000005737, OTTMUSG00000005931, OTTMUSG00000016203, OTTMUSG00000016823, OTTMUSG00000016887, OTTMUSG00000017363, OTTMUSG00000017373, PA1, PDE6D, PEF, PIH1D3, PLCδ1, Polycystin-1L2, PP2B-B1, Prokineticin-2, PRSS50, rapsyn, RDC-1, reticulocalbin-1, S-100A5, SBK1, SERCA2, SLC35B4, Smooth muscle cells, Synaptotagmin IX, Synaptotagmin VI, Synaptotagmin VII, TEF-4, Tescalcin, TEX19.1, TEX21, TEX24, TFIIIC110, Themis, TISP74, TMCO2, TMEM132E, TMEM155, TMEM168, TMEM16E, TMEM174, TMEM175, TMEM202, TMEM38A, TMEM38B, TorsinB, TPCN1, TRBV1, Trichohyalin, TRPC4, TRPC5, TRPC7, TRPM4, TRPM6, TRPV3, TRPV5, TTYH2, V1RE11, VAP-A, Vmn2r21, VR1, VRL-1, WDR7, X123, YPEL2, and zinedin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-APB, 20 mg | sc-201487 | 20 mg | $28.00 | |||
2-APB, 100 mg | sc-201487A | 100 mg | $53.00 |