SLC25A29 Activators
SLC25A29 is a member of the solute carrier family, specifically within the group of mitochondrial transport proteins. These proteins are integral to the mitochondrial membrane and are crucial for the transport of a variety of substrates across the membrane, thereby facilitating fundamental processes such as energy production, metabolism, and maintenance of mitochondrial health. SLC25A29, while not exhaustively characterized, is believed to participate in these essential cellular functions by potentially shuttling compounds into or out of the mitochondria, which could impact various metabolic pathways. Understanding the regulation of SLC25A29 expression is of scientific interest because it could shed light on the intricate network of mitochondrial regulation and its role in cellular homeostasis.
A number of chemical compounds have been identified that could potentially act as activators to induce the expression of SLC25A29. Compounds such as retinoic acid and forskolin may upregulate the expression of SLC25A29 by engaging with cellular signaling pathways that lead to changes in gene transcription. Retinoic acid, for instance, is known to bind to nuclear receptors, which may then bind to DNA at specific response elements to initiate transcriptional activation. Forskolin, through the elevation of cAMP, could lead to the activation of protein kinase A, which in turn may phosphorylate transcription factors that stimulate gene expression. Other compounds like resveratrol and metformin are thought to interact with the cellular energy-sensing pathways, potentially leading to an increase in the expression of genes that are involved in mitochondrial function and biogenesis. Resveratrol may activate sirtuins, while metformin is known to activate AMP-activated protein kinase, both of which are pathways that could signal the need for increased expression of mitochondrial proteins such as SLC25A29. These chemical activators, along with others like sulforaphane and omega-3 fatty acids, highlight the diversity of molecules that can influence the expression of mitochondrial transporters, reflecting the complexity of mitochondrial regulation and the potential adaptability of cellular metabolism to environmental and internal cues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may initiate transcriptional activation of genes, including SLC25A29, through its interaction with nuclear receptors that bind to retinoic acid response elements in promoter regions. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin could elevate intracellular cAMP, leading to the activation of protein kinase A (PKA) and subsequent phosphorylation of transcription factors that may stimulate SLC25A29 gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methylation, 5-Azacytidine could lead to the demethylation of the SLC25A29 gene promoter, thereby removing epigenetic silencing and increasing gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may enhance the expression of SLC25A29 through its role in activating sirtuins, which are known to promote mitochondrial biogenesis and function. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone, through PPAR-gamma activation, could induce the transcription of genes involved in lipid metabolism, which may include an upregulation of the SLC25A29 gene expression as part of a coordinated response to lipid handling. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine may trigger autophagy pathways, leading to the renewal of mitochondrial populations, which in turn could stimulate the upregulation of SLC25A29 to meet new mitochondrial transport needs. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has the potential to activate transcription factors like NF-κB, which could upregulate the transcription of SLC25A29 as part of a cellular defense mechanism against oxidative stress. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetyl-L-cysteine, by providing cysteine for glutathione synthesis, can reduce oxidative stress and possibly induce the expression of genes like SLC25A29 as a compensatory mechanism during oxidative repair processes. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
β-Nicotinamide mononucleotide, by enhancing NAD+ biosynthesis, may promote the activation of sirtuins that are involved in the maintenance of mitochondrial function, potentially leading to the upregulation of SLC25A29 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane can activate the Nrf2 pathway, which stimulates the expression of antioxidant response genes, and may similarly upregulate SLC25A29 as part of the mitochondrial response to oxidative stress. | ||||||