Date published: 2026-5-30

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SLC17A2 Inhibitors

SLC17A2 inhibitors are a class of chemical compounds that specifically target and inhibit the function of the SLC17A2 protein, a member of the solute carrier family. SLC17A2 is part of the larger SLC17 family, which is known for its role in transporting organic anions, including neurotransmitters and other small molecules, across cellular membranes. The inhibition of SLC17A2 can disrupt the transport processes it mediates, offering researchers a powerful tool to study the protein's function and its broader impact on cellular activities. By selectively inhibiting SLC17A2, scientists can explore how this transporter influences the distribution and concentration of specific anions within cells, and how these changes affect cellular metabolism and signaling.

The use of SLC17A2 inhibitors in research is particularly valuable for dissecting the role of this transporter in various biological systems. By blocking SLC17A2 activity, researchers can observe the resulting alterations in cellular processes, such as changes in ion gradients, neurotransmitter release, and intracellular signaling pathways. These studies help to elucidate the specific substrates transported by SLC17A2 and the physiological contexts in which this transporter is most active. Additionally, SLC17A2 inhibitors can be used to explore the regulatory mechanisms that control the expression and activity of this protein, providing insights into how cells maintain homeostasis in response to environmental and intracellular cues. Through these investigations, SLC17A2 inhibitors contribute to a deeper understanding of membrane transport mechanisms and the complex interplay between transport proteins and cellular function.

SEE ALSO...

Items 1 to 10 of 19 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

D(−)-2-Amino-5-phosphonovaleric acid (D-AP5)

79055-68-8sc-200434
5 mg
$97.00
2
(1)

As an NMDA receptor antagonist, AP5 can indirectly influence glutamate signaling and release.

6-Cyano-7-nitroquinoxaline-2,3-dione

115066-14-3sc-505104
10 mg
$208.00
2
(0)

CNQX is a potent AMPA receptor antagonist, indirectly affecting glutamate signaling and release.

Kynurenic acid

492-27-3sc-202683
sc-202683A
sc-202683B
250 mg
1 g
5 g
$26.00
$57.00
$138.00
6
(1)

This is a broad-spectrum antagonist for excitatory amino acid receptors, thus reducing glutamate signaling.

Riluzole

1744-22-5sc-201081
sc-201081A
sc-201081B
sc-201081C
20 mg
100 mg
1 g
25 g
$20.00
$193.00
$213.00
$317.00
1
(1)

Riluzole inhibits the release of glutamate, influencing the function of SLC17A7 indirectly.

Ethosuximide

77-67-8sc-211431
1 g
$306.00
(0)

This compound reduces T-type calcium channel activity, which can indirectly influence glutamate release.

Lamotrigine

84057-84-1sc-201079
sc-201079A
10 mg
50 mg
$120.00
$486.00
1
(1)

Lamotrigine inhibits voltage-sensitive sodium channels, leading to a decrease in glutamate release.

Topiramate

97240-79-4sc-204350
sc-204350A
10 mg
50 mg
$107.00
$369.00
(1)

It modulates GABA-evoked currents, indirectly influencing glutamate release.

Felbamate

25451-15-4sc-203579
sc-203579A
10 mg
50 mg
$101.00
$373.00
(0)

Felbamate acts as a NMDA receptor antagonist, indirectly affecting glutamate signaling and release.

FCCP

370-86-5sc-203578
sc-203578A
10 mg
50 mg
$94.00
$355.00
46
(1)

A protonophore, disrupts proton gradients, potentially influencing SLC17A function.

Niflumic acid

4394-00-7sc-204820
5 g
$32.00
3
(1)

A nonsteroidal anti-inflammatory drug, may indirectly affect ion channels and transporters like SLC17A.