Molecular structure of Riluzole, CAS Number: 1744-22-5
Riluzole (CAS 1744-22-5)
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Alternate Names:
2-Amino-6-(trifluoromethoxy)-benzothiazole
Application:
Riluzole is a sodium channel protein inhibitor
CAS Number:
1744-22-5
Purity:
98%
Molecular Weight:
234.20
Molecular Formula:
C8H5F3N2OS
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Riluzole is a compound with attention in neuroscientific research, especially for its action on glutamatergic transmission. It is used in studies focused on the modulation of synaptic neurotransmitter release, as riluzole may act to have an inhibitory effect on voltage-dependent sodium channels, which can influence glutamate release. This activity makes it useful for researchers investigating the intricacies of excitatory amino acid signaling and its effects on neural networks. Additionally, riluzole′s impact on neuroprotection is a subject of interest in the context of neuronal survival and function under conditions of oxidative stress. Its mechanisms of action provide insights into the cellular processes that relate to neural health and resilience.
Riluzole (CAS 1744-22-5) References
- Anesthetic properties of riluzole (54274 RP), a new inhibitor of glutamate neurotransmission. | Mantz, J., et al. 1992. Anesthesiology. 76: 844-8. PMID: 1349464
- Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia. | Pratt, J., et al. 1992. Neurosci Lett. 140: 225-30. PMID: 1501783
- Do sodium channel blockers have neuroprotective effect after onset of ischemic insult? | Ates, O., et al. 2007. Neurol Res. 29: 317-23. PMID: 17509233
- Therapeutic potential of neuronal two-pore domain potassium-channel modulators. | Mathie, A. and Veale, EL. 2007. Curr Opin Investig Drugs. 8: 555-62. PMID: 17659475
- Riluzole rapidly attenuates hyperemotional responses in olfactory bulbectomized rats, an animal model of depression. | Takahashi, K., et al. 2011. Behav Brain Res. 216: 46-52. PMID: 20620171
- Quantitative estimation of riluzole in human plasma by LC-ESI-MS/MS and its application to a bioequivalence study. | Chandu, BR., et al. 2010. Anal Bioanal Chem. 398: 1367-74. PMID: 20683584
- Pharmacokinetics of Riluzole in Beagle Dogs. | Perdigão, APL., et al. 2019. Drug Res (Stuttg). 69: 40-45. PMID: 29991087
- Riluzole attenuates glutamatergic tone and cognitive decline in AβPP/PS1 mice. | Hascup, KN., et al. 2021. J Neurochem. 156: 513-523. PMID: 33107040
- Riluzole inhibits Kv4.2 channels acting on the closed and closed inactivated states. | Pacheco-Rojas, DO., et al. 2021. Eur J Pharmacol. 899: 174026. PMID: 33722592
- Riluzole restores memory and brain energy metabolism in AβPP-PS1 mouse model of Alzheimer's disease. | Saba, K. and Patel, AB. 2022. Biochem Biophys Res Commun. 610: 140-146. PMID: 35462095
- Riluzole Promotes Neurite Growth in Rats after Spinal Cord Injury through the GSK-3β/CRMP-2 Pathway. | Xu, S., et al. 2022. Biol Pharm Bull. 45: 569-575. PMID: 35491161
- Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway. | Roy, SK., et al. 2022. Sci Rep. 12: 11062. PMID: 35773307
- Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. | Song, JH., et al. 1997. J Pharmacol Exp Ther. 282: 707-14. PMID: 9262334
Inhibitor of:
4930564B18Rik, AARD, AChRα9, Alsin, Aspartoacylase-3, Ataxin-2, C230078M14Rik, CaBP4, Caytaxin, Cerebellin 1, Cerebellin 4, CNG-1β, Complexin-1, CYP1A2, EG632778, ERICH1, FAM194B, FAM69A, GABA T-2, GLUD2, GluR-δ1, GluR-δ2, GlyR β, GRIN1, GRIN2, GRIN3, IGSF9, KV6.3, LEP503, Lingo-3, LRFN5, LRRC8D, Mas 7, mGluR-1, mGluR-6, Mover, N-methyl-D-aspartate (NMDA; GRIN) receptor, Na+ CP type IIIα, Na+ CP type IVα, NCDN, Neu, Neuritin, NF-H, NgR3, NLF1, NMDA zeta 1, NTAL, Olfr824, Olr540, Polycystin-2, Renalase, Rit2, ROG, Serine racemase, Shank2, SLC17A (solute carrier family 17), SLC17A2, SLC38A8, SLC6A (solute carrier family 6), SLC7A12, SNAT1, Sodium Channel Protein, sodium channel type I, sodium channel type II, sodium channel type III, sodium channel type IV, SPBP, SYCE3, Tau, TMEM175, TRESK, Unc79, VGAT, Vmn2r122, Vmn2r33, Vmn2r4, Vmn2r61, and Vmn2r94.Activator of:
ALS2CR11, CDNF, CHERP, CYP2J9, DJ-1, EAAT2, EAAT4, EAT-4, KCC1, KCNH3, KCNT1, KCNV1, KCNV2, LUZP4, MIPEP, NALCN, OBP-2A, p35, parvalbumin α, PIPPIN, SCRN3, Shank 2, SK1, Spatacsin, TASK-1, TASK-5, THIK-1, THIK-2, TREK-1, TWIK-1, TWIK-2, and TWIK-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Riluzole, 20 mg | sc-201081 | 20 mg | $20.00 | |||
Riluzole, 100 mg | sc-201081A | 100 mg | $189.00 | |||
Riluzole, 1 g | sc-201081B | 1 g | $209.00 | |||
Riluzole, 25 g | sc-201081C | 25 g | $311.00 |