Molecular structure of Kynurenic acid, CAS Number: 492-27-3
Kynurenic acid (CAS 492-27-3)
See product citations (6)
Alternate Names:
4-Hydroxyquinoline-2-carboxylic acid
Application:
Kynurenic acid is an antagonist of NMDA and AMPA/kainate receptors
CAS Number:
492-27-3
Purity:
≥97%
Molecular Weight:
189.17
Molecular Formula:
C10H7NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Kynurenic acid is a metabolite of tryptophan in mammals via the kynurenine pathway. Studies have observed that Kynurenic acid acts as a ligand to the GPR35 G protein-coupled receptor. The binding of Kynurenic acid to GPR35 has been noted to affect calcium mobilization and inositol phosphatase synthesis and may indicate potential signaling functions by Kynurenic acid via the GPR35 receptor. Additionally reported to be a broad spectrum, excitatory amino acid (EAA) antagonist. Other studies have reported that Kynurenic acid acts as an antagonist to mammalian ionotropic glutamate receptors especially NMDA (N-methyl-D-aspartate receptors).Kynurenic acid is an inhibitor of AChR alpha7, GluR and GlyR. Also available as a Kynurenic acid, sodium salt (sc-358835)
Kynurenic acid (CAS 492-27-3) References
- Distinguishing between presynaptic and postsynaptic mechanisms of short-term depression during action potential trains. | Wong, AY., et al. 2003. J Neurosci. 23: 4868-77. PMID: 12832509
- Acute and chronic increases in osmolality increase excitatory amino acid drive of the rostral ventrolateral medulla in rats. | Brooks, VL., et al. 2004. Am J Physiol Regul Integr Comp Physiol. 287: R1359-68. PMID: 15319216
- Repeated cocaine administration increases voltage-sensitive calcium currents in response to membrane depolarization in medial prefrontal cortex pyramidal neurons. | Nasif, FJ., et al. 2005. J Neurosci. 25: 3674-9. PMID: 15814798
- Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. | Wang, J., et al. 2006. J Biol Chem. 281: 22021-22028. PMID: 16754668
- Tryptophan metabolism, from nutrition to potential therapeutic applications. | Le Floc'h, N., et al. 2011. Amino Acids. 41: 1195-205. PMID: 20872026
- Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation. | Agudelo, LZ., et al. 2018. Cell Metab. 27: 378-392.e5. PMID: 29414686
- Kynurenic Acid Electrochemical Immunosensor: Blood-Based Diagnosis of Alzheimer's Disease. | Marrugo-Ramírez, J., et al. 2021. Biosensors (Basel). 11: PMID: 33445512
- Reactions of kynurenic acid with hypobromous acid and hypochlorous acid. | Suzuki, T., et al. 2021. J Clin Biochem Nutr. 68: 215-220. PMID: 34025023
- Kynurenic Acid and Its Synthetic Derivatives Protect Against Sepsis-Associated Neutrophil Activation and Brain Mitochondrial Dysfunction in Rats. | Poles, MZ., et al. 2021. Front Immunol. 12: 717157. PMID: 34475875
- Kynurenic acid ameliorates lipopolysaccharide-induced endometritis by regulating the GRP35/NF-κB signaling pathway. | Wang, Y., et al. 2022. Toxicol Appl Pharmacol. 438: 115907. PMID: 35123988
- Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists. | Wyant, GA., et al. 2022. Science. 377: 621-629. PMID: 35926043
- Cellular Regulation of Kynurenic Acid-Induced Cell Apoptosis Pathways in AGS Cells. | Kim, HH., et al. 2022. Int J Mol Sci. 23: PMID: 36012164
- Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. | Yan, J., et al. 2022. EBioMedicine. 84: 104280. PMID: 36174397
- Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35. | Sun, T., et al. 2022. Front Immunol. 13: 1019365. PMID: 36311752
- The 'kynurenate test', a biochemical assay for putative cognition enhancers. | Pittaluga, A., et al. 1997. J Pharmacol Exp Ther. 283: 82-90. PMID: 9336311
Inhibitor of:
CNIH, EAAT-4, GluR, GlyR, GRINA, KA1, Mover, neurexin III, NgR3, NMDA, nyctalopin, SLC17A (solute carrier family 17), SLC17A2, Sp5, V1RA1, and VGAT.Activator of:
Ah Receptor, GABA T-1, and SSc5D.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Kynurenic acid, 250 mg | sc-202683 | 250 mg | $25.00 | |||
Kynurenic acid, 1 g | sc-202683A | 1 g | $56.00 | |||
Kynurenic acid, 5 g | sc-202683B | 5 g | $135.00 |