Molecular structure of Lamotrigine, CAS Number: 84057-84-1
Lamotrigine (CAS 84057-84-1)
See product citations (1)
Alternate Names:
Lamictal; Epilepax; LTG; BW 430C
Application:
Lamotrigine is a sodium channel protein inhibitor
CAS Number:
84057-84-1
Purity:
≥98%
Molecular Weight:
256.09
Molecular Formula:
C9H7Cl2N5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Lamotrigine is a phenyltriazine sodium channel protein inhibitor of presynaptic neurons. Studies indicate that Lamotrigine blocked sustained repetitive firing of neurons in a dose dependent manner in cultured mouse spinal cords. These studies indicate that Lamotrigine is effective at suppressing the release of glutamate and aspartate, but have no effect on acetylcholine and GABA release. Lamotrigine is inactivated by liver microsomes, via hepatic glucuronidation. It is believed that Lamotrigine modulates the fast voltage-dependent sodium currents in a manner similar to phenytoin and carbamazepine (sc-202518). Futhermore, Lamotrigine displays a small frequency dependent inhibition of depolarized potentials that result from sodium currents. Lamotrigine is an inhibitor of Serotonin.
Lamotrigine (CAS 84057-84-1) References
- The anticonvulsant, lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vitro. | Cunningham, MO. and Jones, RS. 2000. Neuropharmacology. 39: 2139-46. PMID: 10963757
- A novel drug binding site on voltage-gated sodium channels in rat brain. | Riddall, DR., et al. 2006. Mol Pharmacol. 69: 278-87. PMID: 16219909
- Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders. | Malik, S., et al. 2006. Expert Rev Neurother. 6: 1609-27. PMID: 17144777
- Lamotrigine is neuroprotective in the energy deficiency model of MPTP intoxicated mice. | Lagrue, E., et al. 2007. Pediatr Res. 62: 14-9. PMID: 17515828
- Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy. | Papazisis, G., et al. 2008. Int J Neuropsychopharmacol. 11: 321-9. PMID: 17897482
- [Optimisation of a high-efficiency liquid chromatography technique for measuring lamotrigine in human plasma]. | Rivas, N., et al. 2010. Farm Hosp. 34: 85-9. PMID: 20304367
- Modulation of the powder properties of lamotrigine by crystal forms. | Kavanagh, ON., et al. 2021. Int J Pharm. 595: 120274. PMID: 33486026
- The Anticonvulsant Lamotrigine Reduces Bout-Like Alcohol Drinking in Rats. | Poceviciute, I., et al. 2022. Alcohol Alcohol. 57: 242-245. PMID: 34718391
- Lamotrigine and retigabine increase motor threshold in transcranial magnetic stimulation at the dose required to produce an antiepileptic effect against maximal electroshock-induced seizure in rats. | Hotta, N., et al. 2022. Neurosci Lett. 771: 136460. PMID: 35051437
- Acute effects of lamotrigine (BW430C) in persons with epilepsy. | Binnie, CD., et al. 1986. Epilepsia. 27: 248-54. PMID: 3698937
- Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: I. Anticonvulsant profile in mice and rats. | Miller, AA., et al. 1986. Epilepsia. 27: 483-9. PMID: 3757935
- Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. | Leach, MJ., et al. 1986. Epilepsia. 27: 490-7. PMID: 3757936
- Lamotrigine (BW430C), a potential anticonvulsant. Effects on the central nervous system in comparison with phenytoin and diazepam. | Cohen, AF., et al. 1985. Br J Clin Pharmacol. 20: 619-29. PMID: 4091994
Inhibitor of:
4930564B18Rik, C8orf68, ERICH1, FAM194B, GABA T-2, GLUD2, GluR-δ1, GluR-δ2, HCN4, IGSF9, LGI2, mGluR-6, Na+ CP type IIIα, Na+ CP type IIIβ, Na+ CP type IVα, NMDAε1, NTAL, Olr235, PCP-2, PRRT2, ROG, SCNM1, Serotonin, SHISA4, SLC17A (solute carrier family 17), SLC17A2, Sodium Channel Protein, sodium channel type I, sodium channel type II, sodium channel type III, sodium channel type IV, SV2A, SV2C, Synapsin IIa, Synaptotagmin III, Synaptotagmin IV, UNC-13, and Unc18-1.Activator of:
CRMP-4, EAAT4, GAD-65, KCNQ2, KCNT2, KV2.1, LGI1, Myo-inositol monophosphatase 1, Myosin-XVA, Na+ CP type Iβ, Na+ CP type IVα, Na+ CP type VIIα, SAPAP1, sodium channel type II, Synapsin Ia/b, and SYP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lamotrigine, 10 mg | sc-201079 | 10 mg | $120.00 | |||
Lamotrigine, 50 mg | sc-201079A | 50 mg | $486.00 |