Molecular structure of Topiramate, CAS Number: 97240-79-4
Topiramate (CAS 97240-79-4)
Alternate Names:
2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulfamate; Topamax
Application:
Topiramate is a GluR5 kainate receptor antagonist which also inhibits Nav channels, L-type Ca2+ channels, and carbonic anhydrase
CAS Number:
97240-79-4
Purity:
≥98%
Molecular Weight:
339.36
Molecular Formula:
C12H21NO8S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Topiramate is a sulfamate-substituted monosaccharide that is a derivative of the sugar monosaccharide D-fructose. In biochemistry, topiramate is known to act on voltage-gated sodium channels, enhance the activity of the neurotransmitter gamma-aminobutyric acid (GABA), and inhibit the activity of the excitatory neurotransmitter glutamate. These actions contribute to its biological effects. Topiramate modulates the activity of certain ion channels and receptors, including AMPA/kainate receptors and carbonic anhydrase enzymes.
Topiramate (CAS 97240-79-4) References
- Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders: a systematic review with direct and network meta-analyses on nalmefene, naltrexone, acamprosate, baclofen and topiramate. | Palpacuer, C., et al. 2018. Addiction. 113: 220-237. PMID: 28940866
- Topiramate in the treatment of cocaine use disorder. | Prince, V. and Bowling, KC. 2018. Am J Health Syst Pharm. 75: e13-e22. PMID: 29273608
- Topiramate Pharmacotherapy for Alcohol Use Disorder and Other Addictions: A Narrative Review. | Manhapra, A., et al. 2019. J Addict Med. 13: 7-22. PMID: 30096077
- Topiramate: Comprehensive profile. | Khalil, NY., et al. 2019. Profiles Drug Subst Excip Relat Methodol. 44: 333-378. PMID: 31029222
- Topiramate, acupuncture, and BoNT-A for chronic migraine: a network meta-analysis. | Zheng, H., et al. 2021. Acta Neurol Scand. 143: 558-568. PMID: 33393102
- Behavioral adverse events with brivaracetam, levetiracetam, perampanel, and topiramate: A systematic review. | Steinhoff, BJ., et al. 2021. Epilepsy Behav. 118: 107939. PMID: 33839453
- CGRP-antibodies, topiramate and botulinum toxin type A in episodic and chronic migraine: A systematic review and meta-analysis. | Frank, F., et al. 2021. Cephalalgia. 41: 1222-1239. PMID: 34130525
- Indirect Comparison of Topiramate and Monoclonal Antibodies Against CGRP or Its Receptor for the Prophylaxis of Episodic Migraine: A Systematic Review with Meta-Analysis. | Overeem, LH., et al. 2021. CNS Drugs. 35: 805-820. PMID: 34272688
- Advances in topiramate as prophylactic treatment for migraine. | Hu, C., et al. 2021. Brain Behav. 11: e2290. PMID: 34472696
- Topiramate for juvenile myoclonic epilepsy. | Liu, J., et al. 2021. Cochrane Database Syst Rev. 11: CD010008. PMID: 34817852
- Topiramate for Weight Management in Children With Severe Obesity. | Berman, C., et al. 2023. Child Obes. 19: 219-225. PMID: 35767803
- Phentermine/Topiramate: Pediatric First Approval. | Dhillon, S. 2022. Paediatr Drugs. 24: 715-720. PMID: 36059008
- More concerns over safety of topiramate in pregnancy. | . 2022. Drug Ther Bull. 60: 165. PMID: 36220338
Inhibitor of:
4930564B18Rik, ADHβ, AE4, AMPA 1, AMPA 2, AMPA 3, AMPA 4, CA II, CA III, CA IV, CA VI, CA VII, CA XII, CA XIII, CA XV, Carbonic Anhydrases, CNIH3, CSAD, CYP2C19, ERICH1, FAM194B, GABA T-2, GAD-25, GADL1, GLUD2, GluR-δ1, GluR-δ2, GluR-5, GSG1L, IMP-3, IMPA3, KA1, LGI2, mGluR-6, NBC4, NCBE, Olfr826, Olr235, OPN1MW, PCP-2, Per2, PNKD, retbindin, ROG, SHISA9, SLC17A (solute carrier family 17), SLC17A2, SLC4A (Solute carrier family 4), and SLC4A7.Activator of:
AE3, CA I, EAAT4, KCNT2, and LGI1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Topiramate, 10 mg | sc-204350 | 10 mg | $107.00 | |||
Topiramate, 50 mg | sc-204350A | 50 mg | $369.00 |