SLC17A2 inhibitors are a class of chemical compounds that specifically target and inhibit the function of the SLC17A2 protein, a member of the solute carrier family. SLC17A2 is part of the larger SLC17 family, which is known for its role in transporting organic anions, including neurotransmitters and other small molecules, across cellular membranes. The inhibition of SLC17A2 can disrupt the transport processes it mediates, offering researchers a powerful tool to study the protein's function and its broader impact on cellular activities. By selectively inhibiting SLC17A2, scientists can explore how this transporter influences the distribution and concentration of specific anions within cells, and how these changes affect cellular metabolism and signaling.
The use of SLC17A2 inhibitors in research is particularly valuable for dissecting the role of this transporter in various biological systems. By blocking SLC17A2 activity, researchers can observe the resulting alterations in cellular processes, such as changes in ion gradients, neurotransmitter release, and intracellular signaling pathways. These studies help to elucidate the specific substrates transported by SLC17A2 and the physiological contexts in which this transporter is most active. Additionally, SLC17A2 inhibitors can be used to explore the regulatory mechanisms that control the expression and activity of this protein, providing insights into how cells maintain homeostasis in response to environmental and intracellular cues. Through these investigations, SLC17A2 inhibitors contribute to a deeper understanding of membrane transport mechanisms and the complex interplay between transport proteins and cellular function.
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| Nome do Produto | CAS # | Numero de Catalogo | Quantidade | Preco | Uso e aplicacao | NOTAS |
|---|---|---|---|---|---|---|
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
Inibe competitivamente vários transportadores de aniões, reduzindo potencialmente a função dos membros da família SLC17. | ||||||
Phloridzin | 60-81-1 | sc-219613 | 2.5 g | $388.00 | ||
Inibe os transportadores dependentes de sódio, podendo reduzir a captação competitiva de fosfato. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Inibe indiretamente os transportadores de aniões ao afetar a síntese de prostaglandinas, alterando a dinâmica do transporte renal. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $40.00 | ||
Um diurético de ansa que inibe o NKCC2, pode ter efeitos secundários no transporte de fosfato. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $107.00 $224.00 | 9 | |
Semelhante à furosemida, inibe a NKCC2, o que pode influenciar indiretamente a atividade da SLC17A. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Afecta a inositol monofosfatase, levando a alterações no transporte de aniões, podendo alterar a função do SLC17A. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Altera o metabolismo dos lípidos e pode influenciar os transportadores de membrana, modificando as propriedades da membrana. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $54.00 $235.00 $326.00 $551.00 $969.00 | ||
Um diurético tiazídico que afecta a reabsorção de electrólitos, pode afetar indiretamente o transporte relacionado com o SLC17A. | ||||||
Chlorothiazide | 58-94-6 | sc-202536 sc-202536A sc-202536B | 1 g 5 g 10 g | $38.00 $105.00 $172.00 | ||
Semelhante à hidroclorotiazida, pode ter um efeito indireto na atividade do SLC17A ao alterar o equilíbrio iónico. | ||||||