SLC17A2 inhibitors are a class of chemical compounds that specifically target and inhibit the function of the SLC17A2 protein, a member of the solute carrier family. SLC17A2 is part of the larger SLC17 family, which is known for its role in transporting organic anions, including neurotransmitters and other small molecules, across cellular membranes. The inhibition of SLC17A2 can disrupt the transport processes it mediates, offering researchers a powerful tool to study the protein's function and its broader impact on cellular activities. By selectively inhibiting SLC17A2, scientists can explore how this transporter influences the distribution and concentration of specific anions within cells, and how these changes affect cellular metabolism and signaling.
The use of SLC17A2 inhibitors in research is particularly valuable for dissecting the role of this transporter in various biological systems. By blocking SLC17A2 activity, researchers can observe the resulting alterations in cellular processes, such as changes in ion gradients, neurotransmitter release, and intracellular signaling pathways. These studies help to elucidate the specific substrates transported by SLC17A2 and the physiological contexts in which this transporter is most active. Additionally, SLC17A2 inhibitors can be used to explore the regulatory mechanisms that control the expression and activity of this protein, providing insights into how cells maintain homeostasis in response to environmental and intracellular cues. Through these investigations, SLC17A2 inhibitors contribute to a deeper understanding of membrane transport mechanisms and the complex interplay between transport proteins and cellular function.
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| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Inhibe de manière compétitive divers transporteurs d'anions, réduisant potentiellement la fonction des membres de la famille SLC17. | ||||||
Phloridzin | 60-81-1 | sc-219613 | 2.5 g | $396.00 | ||
Inhibe les transporteurs dépendants du sodium, pourrait réduire l'absorption compétitive du phosphate. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Inhibe indirectement les transporteurs d'anions en affectant la synthèse des prostaglandines, ce qui modifie la dynamique du transport rénal. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $41.00 | ||
Diurétique de l'anse qui inhibe le NKCC2, peut avoir des effets secondaires sur le transport du phosphate. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $109.00 $228.00 | 9 | |
Similaire au furosémide, inhibe le NKCC2, ce qui pourrait influencer indirectement l'activité du SLC17A. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Affecte l'inositol monophosphatase, entraînant des changements dans le transport des anions, ce qui pourrait modifier la fonction du SLC17A. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Modifie le métabolisme des lipides et peut influencer les transporteurs membranaires en modifiant les propriétés de la membrane. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $55.00 $240.00 $333.00 $562.00 $988.00 | ||
Un diurétique thiazidique qui affecte la réabsorption des électrolytes, pourrait indirectement affecter le transport lié à la SLC17A. | ||||||
Chlorothiazide | 58-94-6 | sc-202536 sc-202536A sc-202536B | 1 g 5 g 10 g | $39.00 $107.00 $175.00 | ||
Comme l'hydrochlorothiazide, il pourrait avoir un effet indirect sur l'activité de la SLC17A en modifiant l'équilibre ionique. | ||||||