SLC17A2 inhibitors are a class of chemical compounds that specifically target and inhibit the function of the SLC17A2 protein, a member of the solute carrier family. SLC17A2 is part of the larger SLC17 family, which is known for its role in transporting organic anions, including neurotransmitters and other small molecules, across cellular membranes. The inhibition of SLC17A2 can disrupt the transport processes it mediates, offering researchers a powerful tool to study the protein's function and its broader impact on cellular activities. By selectively inhibiting SLC17A2, scientists can explore how this transporter influences the distribution and concentration of specific anions within cells, and how these changes affect cellular metabolism and signaling.
The use of SLC17A2 inhibitors in research is particularly valuable for dissecting the role of this transporter in various biological systems. By blocking SLC17A2 activity, researchers can observe the resulting alterations in cellular processes, such as changes in ion gradients, neurotransmitter release, and intracellular signaling pathways. These studies help to elucidate the specific substrates transported by SLC17A2 and the physiological contexts in which this transporter is most active. Additionally, SLC17A2 inhibitors can be used to explore the regulatory mechanisms that control the expression and activity of this protein, providing insights into how cells maintain homeostasis in response to environmental and intracellular cues. Through these investigations, SLC17A2 inhibitors contribute to a deeper understanding of membrane transport mechanisms and the complex interplay between transport proteins and cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Competitively inhibits various anion transporters, potentially reducing the function of SLC17 family members. | ||||||
Phloridzin | 60-81-1 | sc-219613 | 2.5 g | $396.00 | ||
Inhibits sodium-dependent transporters, might reduce competitive uptake of phosphate. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Inhibits anion transporters indirectly by affecting prostaglandin synthesis, altering renal transport dynamics. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $41.00 | ||
A loop diuretic that inhibits the NKCC2, can have secondary effects on phosphate transport. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $109.00 $228.00 | 9 | |
Similar to Furosemide, inhibits NKCC2 which could indirectly influence SLC17A activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Affects inositol monophosphatase leading to changes in anion transport, could alter SLC17A function. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Alters lipid metabolism and can influence membrane transporters by modifying membrane properties. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $55.00 $240.00 $333.00 $562.00 $988.00 | ||
A thiazide diuretic that affects electrolyte reabsorption, could indirectly affect SLC17A-related transport. | ||||||
Chlorothiazide | 58-94-6 | sc-202536 sc-202536A sc-202536B | 1 g 5 g 10 g | $39.00 $107.00 $175.00 | ||
Similar to Hydrochlorothiazide, could have an indirect effect on SLC17A activity by altering ion balance. | ||||||