Molecular structure of Bumetanide (Ro 10-6338), CAS Number: 28395-03-1
Bumetanide (Ro 10-6338) (CAS 28395-03-1)
See product citations (9)
Alternate Names:
3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-benzoic acid; PF 1593
Application:
Bumetanide (Ro 10-6338) is a specific inhibitor of Na+-K+-2Cl- cotransporter NKCC1
CAS Number:
28395-03-1
Purity:
≥98%
Molecular Weight:
364.42
Molecular Formula:
C17H20N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bumetanide (Ro 10-6338) is a specific inhibitor of Na+-K+-2Cl- cotransporter NKCC1, which may act to bind with high affinity and saturate binding of the cotransporter. The inhibitor has been reported to bind to different cell membranes, including HeLa cells, vascular muscle cells, endothelial cell, erythrocyte cells, and colonic adenocarcinoma cells, among others. Furthermore, Bumetanide has been observed to block the depolarization of GABA in cortical development studies.
Bumetanide (Ro 10-6338) (CAS 28395-03-1) References
- Bumetanide inhibits rapid kindling in neonatal rats. | Mazarati, A., et al. 2009. Epilepsia. 50: 2117-22. PMID: 19260939
- Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1. | Kahle, KT., et al. 2009. J Child Neurol. 24: 572-6. PMID: 19406757
- Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy. | Brandt, C., et al. 2010. J Neurosci. 30: 8602-12. PMID: 20573906
- Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits. | Wang, DD. and Kriegstein, AR. 2011. Cereb Cortex. 21: 574-87. PMID: 20624842
- The regulation of Na/K/2Cl cotransport and bumetanide binding in avian erythrocytes by protein phosphorylation and dephosphorylation. Effects of kinase inhibitors and okadaic acid. | Pewitt, EB., et al. 1990. J Biol Chem. 265: 20747-56. PMID: 2147426
- Effect of bradykinin on Na-K-2Cl cotransport and bumetanide binding in aortic endothelial cells. | Klein, JD. and O'Neill, WC. 1990. J Biol Chem. 265: 22238-42. PMID: 2266124
- Bumetanide Derivatives AqB007 and AqB011 Selectively Block the Aquaporin-1 Ion Channel Conductance and Slow Cancer Cell Migration. | Kourghi, M., et al. 2016. Mol Pharmacol. 89: 133-40. PMID: 26467039
- Bumetanide stimulation of sodium permeability of the apical membrane of toad urinary bladder. | Li, JH. and Kau, ST. 1988. J Pharmacol Exp Ther. 246: 980-5. PMID: 2843638
- Bumetanide blocks the acquisition of conditioned fear in adult rats. | Ko, MC., et al. 2018. Br J Pharmacol. 175: 1580-1589. PMID: 29235092
- Bumetanide-Derived Aquaporin 1 Inhibitors, AqB013 and AqB050 Inhibit Tube Formation of Endothelial Cells through Induction of Apoptosis and Impaired Migration In Vitro. | Tomita, Y., et al. 2019. Int J Mol Sci. 20: PMID: 31013775
- Luminal disequilibrium pH and ammonia transport in outer medullary collecting duct [corrected and issued with original paging in Am J Physiol 1987 Aug;253(2 Pt 2)]. | Star, RA., et al. 1987. Am J Physiol. 252: F1148-57. PMID: 3109255
- Characteristics and functions of Na-K-Cl cotransport in epithelial tissues. | O'Grady, SM., et al. 1987. Am J Physiol. 253: C177-92. PMID: 3303961
- Bumetanide-induced diuresis and natriuresis: effect of prostaglandin synthetase inhibition. | Kaufman, J., et al. 1981. J Clin Pharmacol. 21: 663-7. PMID: 6802882
Inhibitor of:
βENaC, AQP1, AQP2, AQP3, AQP4, C20orf111, C4ST-2, C8orf5, CA XII, Claudin (CLDN), claudin-2, CLC-3, CLC-6, CLCA3_Clac3, CLCA5_Clac5, Clca6, Eapa2, FAM18B, FXYD7, GPR89, GPR89B, Inhibitors, KCC1, KCC2b, LRRC8B, LRRC8C, LRRC8D, MCT1, MCT12, Na+ CP type Vα, Na+ CP type XIα, NCBE, NHEDC2, NKAIN1, NKCC1, NKHC1, NPT1, Olr411, OSR1, OTOP3, PIPES, Prestin, SLC12A8, SLC12A9, SLC17A (solute carrier family 17), SLC17A2, SLC17A4, SLC41A1, Stereocilin, TMC6, TMEM14A, TMEM16J, TMEM16K, TMEM17, TMEM63B, and TMEM87B.Activator of:
αENaC, AE3, CA VB, CLC-4, CLCC1, CLIC2, KCC1, KCC4, Na+ CP type IIIβ, NHE-5, NHE-7, NKAIN1, NKCC1, OXSR1, SLC26A11, SLC41A3, SMVT_Slc5a6, TMC1, and TTYH1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bumetanide (Ro 10-6338), 1 g | sc-200727 | 1 g | $109.00 | |||
Bumetanide (Ro 10-6338), 5 g | sc-200727A | 5 g | $228.00 |