MF: C21H24O10 MW: 436.41 An SGLT-1 and SGLT-2 inhibitor found in apple trees.
Protein-Interacting Inhibitors, Activators & Substrates
Phloridzin (CAS 60-81-1)
Phloridzin is an SGLT-1 and SGLT-2 inhibitor found in apple trees
C 21H 24O 10
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For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. *
Certificate of Analysis for lot specific data (including water content).
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Phloridzin is a dihydrochalcone found in all parts of the apple tree, except the mature fruit, and acts as an inhibitor of SGLT-1 and SGLT-2.
1. Moelwyn-Hughes, J., et al.: Gen. Physiol., 13,807 (1930)
2. Bridel, K., et al.: Bull. Soc. Chim. Biol., 15, 544 (1933)
Soluble in DMSO (100 mM), methanol, acetone, ethanol (100 mM), and water (partly).
>126° C (dec.)
~770.0° C at 760 mmHg (Predicted)
20 D 1.69 (Predicted)
50 = 16 nM (human); COS-1 cells expressing hSGLT2: IC 50 = 65 nM (human); SGLT-1: IC 50 = 185 nM (human); COS-1 cells expressing hSGLT1: IC 50 = 400 nM (human); Tyrosinase: IC 50 = 110 µM (mushroom)
i= 11 nM; SGLT1: K i= 140 nM; CNT3: K i= 16 µM; Tyrosinase: K i= 64.3 µM (Agaricus bisporus); ENT1: K i>1000 µM (human)
a: 7.15 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
UN 3077, Class 9, Packing group III
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