Molecular structure of Phloridzin, CAS Number: 60-81-1
Phloridzin (CAS 60-81-1)
Application:
Phloridzin is an SGLT-1 and SGLT-2 inhibitor found in apple trees
CAS Number:
60-81-1
Purity:
95%
Molecular Weight:
436.41
Molecular Formula:
C21H24O10
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Phloridzin is a dihydrochalcone found in all parts of the apple tree, except the mature fruit, and acts as an inhibitor of SGLT-1 and SGLT-2.Extensive laboratory investigations have been conducted to explore its potential uses. phlorizin inhibiting key enzymes involved in glucose metabolism, such as glucokinase, aldose reductase, and glycogen synthase.
Phloridzin (CAS 60-81-1) References
- Phloridzin: biosynthesis, distribution and physiological relevance in plants. | Gosch, C., et al. 2010. Phytochemistry. 71: 838-43. PMID: 20356611
- Phloridzin improves lipoprotein lipase activity in stress-loaded mice via AMPK phosphorylation. | Wang, GE., et al. 2014. Int J Food Sci Nutr. 65: 874-80. PMID: 24932810
- Phloridzin derivatives inhibiting pro-inflammatory cytokine expression in human cystic fibrosis IB3-1 cells. | Milani, R., et al. 2015. Eur J Pharm Sci. 78: 225-33. PMID: 26209880
- Phloridzin inhibits high K+-induced contraction via the inhibition of sodium: glucose cotransporter 1 in rat ileum. | Kanda, H., et al. 2017. J Vet Med Sci. 79: 593-601. PMID: 28190822
- Phloridzin, an Apple Polyphenol, Exerted Unfavorable Effects on Bone and Muscle in an Experimental Model of Type 2 Diabetes in Rats. | Londzin, P., et al. 2018. Nutrients. 10: PMID: 30405066
- Dietary intake of phloridzin from natural occurrence in foods. | Niederberger, KE., et al. 2020. Br J Nutr. 123: 942-950. PMID: 31910912
- Radiolytic Cyclization Products of Phloridzin as Potent Anti-Glycation Agents. | Jeong, GH. and Kim, TH. 2020. Chem Biodivers. 17: e2000305. PMID: 32627292
- The Bioavailability, Extraction, Biosynthesis and Distribution of Natural Dihydrochalcone: Phloridzin. | Tian, L., et al. 2021. Int J Mol Sci. 22: PMID: 33478062
- Effects of phloridzin on blood glucose and key enzyme G-6-Pase of gluconeogenesis in mice. | Wang, JZ., et al. 2021. J Food Biochem. 45: e13956. PMID: 34590315
- Ameliorative potential of phloridzin in type 2 diabetes-induced memory deficits in rats. | Kamdi, SP., et al. 2021. Eur J Pharmacol. 913: 174645. PMID: 34800467
- Phloridzin Highly Accumulated in Malus rockii Rehder and Its Structure Revision and Hypolipidemic Activity. | Lang, LJ., et al. 2022. Planta Med. 88: 1190-1198. PMID: 34875697
- Docosahexaenoic Acid Ester of Phloridzin Reduces Inflammation and Insulin Resistance via AMPK. | Chen, J., et al. 2022. Curr Pharm Des. 28: 1854-1862. PMID: 35585811
- Hepatoprotective Effects of Phloridzin against Isoniazid-Rifampicin Induced Liver Injury by Regulating CYP450 and Nrf2/HO-1 Pathway in Mice. | Yang, J., et al. 2022. Chem Pharm Bull (Tokyo). 70: 805-811. PMID: 36070932
Inhibitor of:
SGLT-1, SGLT-2, SLC17A2, and ZnT-6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phloridzin, 2.5 g | sc-219613 | 2.5 g | $388.00 |