SKAP55 Activators
SKAP55 activators belong to a unique class of chemical compounds that play a crucial role in the regulation of cellular signaling pathways. These activators are designed to specifically target and modulate the activity of SKAP55 (Src kinase-associated phosphoprotein of 55 kDa), a protein that serves as a key mediator in various cellular processes. SKAP55 itself is an adaptor protein that is primarily associated with immune cells, where it plays a pivotal role in the activation and regulation of immune responses.
The chemical class of SKAP55 activators is characterized by its ability to enhance or inhibit the function of SKAP55, depending on the specific compound and its mechanism of action. These compounds can either enhance the phosphorylation of SKAP55 or inhibit its binding to other signaling molecules, thereby influencing downstream signaling events. By targeting SKAP55, these activators can potentially modulate cellular processes such as immune cell activation, cell adhesion, and cytoskeletal rearrangements. This makes them valuable tools for researchers studying the intricacies of immune system function and cell signaling pathways. Understanding the mechanisms and effects of SKAP55 activators can shed light on the fundamental processes that govern immune responses and cell behavior.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC) which can phosphorylate SKAP55, thereby enhancing its activity in T-cell receptor signaling and integrin activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels, which activates PKA. PKA can phosphorylate substrates that may include SKAP55, potentially enhancing its role in T-cell activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin raises intracellular calcium levels which can activate calcineurin. Activated calcineurin can dephosphorylate proteins that can interact with SKAP55, possibly facilitating its function in T-cell signaling. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a PKC inhibitor that in some contexts can enhance T-cell activation by shifting the balance of PKC isoforms, potentially indirectly upregulating SKAP55 function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels within cells. This could indirectly enhance SKAP55 activity by maintaining its phosphorylation state. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Like Okadaic Acid, Calyculin A inhibits PP1 and PP2A, potentially increasing the phosphorylation and thus the activity of SKAP55 in T-cell receptor mediated signaling. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can inhibit certain protein kinases, which might reduce negative regulatory phosphorylation events, thus potentially enhancing the activation state of SKAP55. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cAMP analog that activates PKA. PKA-mediated phosphorylation events can enhance the activity of SKAP55 in signaling pathways of lymphocytes. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A inhibits calcineurin, which can increase the activity of NFAT-controlled genes. Through complex T-cell signaling pathways, this might enhance the role of SKAP55 in T-cell activation. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $138.00 $530.00 | 24 | |
Prostratin activates PKC isoforms, potentially leading to phosphorylation events that enhance SKAP55 function in T-cell adhesion and costimulation. | ||||||