Six1 Inhibitors
Six1 inhibitors encompass a diverse array of chemicals that modulate Six1 activity through various mechanisms. BIX 01294, EPZ-6438, and GSK-J4 are direct inhibitors targeting epigenetic regulators G9a, EZH2, and KDM6B, respectively. They disrupt histone modifications, leading to altered chromatin structure and transcriptional repression of Six1. Trichostatin A and OTX015 are direct inhibitors that target histone deacetylases and BET proteins, respectively, influencing Six1 at the chromatin level.
Curcumin and Flavopiridol are indirect inhibitors impacting Six1 through TGF-β signaling and cell cycle regulation, respectively. DAPT and JQ1 indirectly modulate Six1 through Notch signaling and BET proteins, respectively. MLN4924 indirectly influences Six1 by targeting the NEDDylation pathway, stabilizing Six1. ATRA acts as an indirect inhibitor by activating retinoic acid receptors, inducing transcriptional repression of Six1. PFI-3, another BET inhibitor, directly interferes with BET proteins, contributing to altered chromatin structure and transcriptional repression of Six1. This diverse group of Six1 inhibitors provides valuable tools for studying the intricate regulation of Six1 in various cellular contexts. The detailed understanding of these inhibitors and their specific actions on Six1 contributes to unraveling the complex networks that govern Six1 expression and activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX 01294 is a direct inhibitor of Six1, targeting the lysine methyltransferase G9a. By inhibiting G9a, BIX 01294 disrupts the methylation of histone H3, leading to altered chromatin structure and transcriptional repression of Six1. This direct interference with the epigenetic regulation of Six1 expression establishes BIX 01294 as a chemical inhibitor with the potential to modulate Six1 activity at the chromatin level. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
EPZ-6438 is a direct inhibitor of Six1, targeting the enhancer of zeste homolog 2 (EZH2). By inhibiting EZH2, a histone methyltransferase, EPZ-6438 disrupts the methylation of histone H3 at lysine 27, resulting in altered chromatin structure and transcriptional repression of Six1. This direct interference with the epigenetic regulation of Six1 expression establishes EPZ-6438 as a chemical inhibitor with the potential to modulate Six1 activity at the chromatin level. | ||||||
GSK-J4 | 1373423-53-0 | sc-507551 | 100 mg | $1275.00 | ||
GSK-J4 is a direct inhibitor of Six1 that targets lysine demethylase 6B (KDM6B or JMJD3). By inhibiting KDM6B, GSK-J4 prevents the demethylation of histone H3 at lysine 27, leading to altered chromatin structure and transcriptional repression of Six1. This direct interference with the epigenetic regulation of Six1 expression establishes GSK-J4 as a chemical inhibitor with the potential to modulate Six1 activity at the chromatin level. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is an indirect inhibitor of Six1 that influences the TGF-β signaling pathway. By inhibiting TGF-β receptor activation and downstream Smad signaling, curcumin suppresses the expression of Six1. This indirect modulation of Six1 through TGF-β signaling showcases the potential of curcumin to impact Six1 expression and activity in cellular contexts where TGF-β signaling is crucial for Six1 regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a direct inhibitor of Six1 that targets histone deacetylases (HDACs). By inhibiting HDACs, trichostatin A prevents the deacetylation of histones, leading to altered chromatin structure and transcriptional repression of Six1. This direct interference with the epigenetic regulation of Six1 expression establishes trichostatin A as a chemical inhibitor with the potential to modulate Six1 activity at the chromatin level. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol is a direct inhibitor of Six1, acting as a cyclin-dependent kinase (CDK) inhibitor. By inhibiting CDKs, flavopiridol disrupts the cell cycle, leading to decreased expression of Six1. This direct interference with the cell cycle-dependent regulation of Six1 expression establishes flavopiridol as a chemical inhibitor with the potential to modulate Six1 activity in a cell cycle-dependent manner. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT is an indirect inhibitor of Six1 that targets the Notch signaling pathway. By inhibiting γ-secretase, DAPT prevents the cleavage of Notch receptors, leading to reduced Notch signaling and subsequent suppression of Six1 expression. This indirect modulation of Six1 through Notch signaling highlights the potential of DAPT to impact Six1 expression and activity in cellular contexts where Notch signaling is crucial for Six1 regulation. | ||||||
(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide | 202590-98-5 | sc-501130 | 2.5 mg | $330.00 | ||
Also called OTX015, this compound is a direct inhibitor of Six1, targeting the bromodomain and extra-terminal (BET) family of proteins. By inhibiting BET proteins, OTX015 disrupts the binding of BET proteins to acetylated histones, leading to altered chromatin structure and transcriptional repression of Six1. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 is an indirect inhibitor of Six1 that influences the NEDDylation pathway. By inhibiting NEDDylation, MLN4924 disrupts the activation of Cullin-RING ligases (CRLs), leading to the stabilization of CRL substrates, including Six1. This indirect modulation of Six1 through the NEDDylation pathway showcases the potential of MLN4924 to impact Six1 expression and activity in cellular contexts where NEDDylation is crucial for Six1 regulation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a direct inhibitor of Six1, targeting the bromodomain and extra-terminal (BET) family of proteins. By inhibiting BET proteins, JQ1 disrupts the binding of BET proteins to acetylated histones, leading to altered chromatin structure and transcriptional repression of Six1. This direct interference with the epigenetic regulation of Six1 expression establishes JQ1 as a chemical inhibitor with the potential to modulate Six1 activity at the chromatin level. | ||||||