Date published: 2025-10-4

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SIRT1 Inhibitors

SIRT1 inhibitors belong to a class of chemical compounds that primarily target and modulate the activity of the SIRT1 enzyme. SIRT1, short for Silent Information Regulator 2 homolog 1, is a member of the sirtuin family of enzymes, which are involved in various cellular processes, including gene regulation, DNA repair, metabolism, and stress response. These inhibitors are designed to interact with the active site of the SIRT1 enzyme, thereby altering its catalytic function. By influencing SIRT1 activity, these inhibitors can impact cellular processes that are regulated by this enzyme.Structurally, SIRT1 inhibitors often exhibit a diverse range of chemical scaffolds, allowing for variations in their binding affinity and selectivity towards the SIRT1 enzyme. Many of these compounds possess specific functional groups and molecular features that facilitate their interaction with key residues in the active site of the enzyme. This interaction can result in the inhibition of SIRT1's deacetylase activity, which is responsible for removing acetyl groups from target proteins. By modulating this enzymatic activity, SIRT1 inhibitors have the ability to influence acetylation-dependent cellular pathways, and thus, they have garnered significant attention in scientific research. In recent years, studies have focused on elucidating the role of SIRT1 inhibitors in cellular and molecular processes. The investigation of SIRT1 inhibitors provides insights into the complex regulatory networks within cells and offers a deeper understanding of the role of SIRT1 in maintaining cellular homeostasis.

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Items 1 to 10 of 17 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

EX 527

49843-98-3sc-203044
5 mg
$85.00
32
(1)

This compound is a potent and selective SIRT1 inhibitor that has been used in various research studies to investigate the role of SIRT1 in cellular processes.

Suramin sodium

129-46-4sc-507209
sc-507209F
sc-507209A
sc-507209B
sc-507209C
sc-507209D
sc-507209E
50 mg
100 mg
250 mg
1 g
10 g
25 g
50 g
$149.00
$210.00
$714.00
$2550.00
$10750.00
$21410.00
$40290.00
5
(1)

Suramin sodium (CAS 129-46-4) is a chemical compound recognized for its role as an inhibitor of SIRT1, a protein associated with cellular processes. It modulates biological pathways through its interaction with SIRT1, impacting cellular functions.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

A natural polyphenol found in red grapes, resveratrol is a well-known SIRT1 activator that has been studied for its potential anti-aging effects.

SIRT1 Inhibitor IV, (S)-35

848193-72-6sc-204279
500 µg
$224.00
4
(1)

SIRT1 Inhibitor IV, (S)-35 (CAS 848193-72-6) is a chemical compound that acts as an inhibitor of SIRT1, a protein involved in cellular processes. It modulates SIRT1 activity through its distinctive structure, influencing relevant pathways.

Sirtinol

410536-97-9sc-205976
sc-205976A
1 mg
5 mg
$37.00
$111.00
14
(1)

Sirtinol is a small molecule inhibitor that targets both SIRT1 and SIRT2 enzymes, affecting their deacetylase activity.

Tenovin-6

1011557-82-6sc-224296
sc-224296A
1 mg
5 mg
$272.00
$1214.00
9
(1)

Tenovin-6 (CAS 1011557-82-6) is a chemical compound that functions as an inhibitor of SIRT1, a protein associated with cellular regulation. It modulates SIRT1 activity, impacting cellular processes.

SIRT1/2 Inhibitor IV, Cambinol

14513-15-6sc-204280
5 mg
$142.00
4
(1)

Another SIRT1 and SIRT2 inhibitor, cambinol has been studied for its potential anti-cancer properties and effects on cellular metabolism.

Tenovin-1

380315-80-0sc-222342
10 mg
$87.00
1
(1)

Tenovin-1 is a SIRT1 and SIRT2 inhibitor that has demonstrated anticancer effects in preclinical studies.

Dihydrocoumarin

119-84-6sc-227867
sc-227867A
5 g
25 g
$17.00
$41.00
(0)

Dihydrocoumarin (CAS 119-84-6) is recognized for its role as an inhibitor of SIRT1, a protein associated with cellular regulation. It has properties that affect cellular processes.

SIRT1/2 Inhibitor VII

143034-06-4sc-364618
10 mg
$113.00
(0)

SIRT1/2 Inhibitor VII (CAS 143034-06-4) is a chemical compound known for its role as an inhibitor of SIRT1 enzyme activity. It modulates cellular processes through SIRT1 inhibition, impacting various biological pathways.