Tenovin-6 (CAS 1011557-82-6)

Tenovin-6, a small molecule inhibitor, effectively targets the transcription factor NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells). This potent and selective inhibitor has found extensive use in diverse scientific research applications. Through its specific focus on NF-κB, Tenovin-6 exhibits robust inhibitory activity, demonstrated in various models. Notably, it is the water-soluble analog of Tenovin-1 (sc-222342) and acts as a powerful inhibitor of SIRT1 and SIRT2, while also activating p53. SIRT1 and SIRT2 belong to the NAD+-dependent class III histone deacetylases, known as protein-deacetylases, which have been associated with the regulation of epigenetic gene expression in yeast. Comparative studies indicate that Tenovin-6 surpasses Tenovin-1 (sc-222342) in enhancing p53 levels and exhibits higher toxicity towards yeast. Furthermore, Tenovin-6 has been found to inhibit SIRT3. The biochemical and physiological effects of Tenovin-6 are diverse. For instance, in a study involving a mouse model of acute inflammation, Tenovin-6 demonstrated its ability to inhibit the expression of pro-inflammatory cytokines, namely IL-1β and TNF-α. Similarly, in a mouse model of sepsis, it was observed that Tenovin-6 effectively suppressed the expression of NF-κB-regulated genes. Moreover, Tenovin-6 showcased its capability to reduce the production of reactive oxygen species in a human endothelial cell line. These findings underscore the multifaceted impact of Tenovin-6 across various biological processes, solidifying its significance in scientific exploration.