Tenovin-6 CAS: 1011557-82-6
Tenovin-6 is an inhibitor of SIRT1, SIRT2, and SIRT3 and activator of p53.

Tenovin-6 (CAS 1011557-82-6)

Tenovin-6 | CAS 1011557-82-6 is rated 5.0 out of 5 by 1.
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Alternate Names: N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4- (1,1-dimethylethyl)-benzamide
Application: Tenovin-6 is an inhibitor of SIRT1, SIRT2, and SIRT3 and activator of p53
CAS Number: 1011557-82-6
Purity: ≥95%
Molecular Weight: 454.6
Molecular Formula: C25H34N4O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Tenovin-6 is the water soluble analog of Tenovin-1 (sc-222342) and acts as a potent SIRT1 and SIRT2 inhibitor as well as p53 activator. SIRT1 and SIRT2 are protein-deacetylases that belong to the NAD+-dependent class III histone deacetylases. Although the function of sirtuins in humans is not entirely known, in yeast, they have been shown to regulate epigenetic gene expression. Studies show that tenovin-6 increases p53 levels more than tenovin-1 (sc-222342) and is also more toxic to yeast. Tenovin-6 has also been shown to inhibit SIRT3.


References

1. Brooks, C.L. and Gu, W. 2008. Cancer Cell. 13: 377-378. PMID: 18455119
2. Lain, S., et al. 2008. Cancer Cell. 13: 454-463. PMID: 18455128
3. Liu, T., et al. 2009. Cancer Res. 69: 1702-1705. PMID: 19244112

Physical State :
Solid
Solubility :
Soluble in ethanol (~1 mg/ml), and DMSO (~20 mg/ml).
Storage :
Store at -20° C
Density :
1.17 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
SIRT2: IC50 = 10 µM; SIRT1: IC50 = 21 µM; SIRT3: IC50 = 67 µM
pK Values :
pKa: 9.11 (Predicted), pKb: 9.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24772043
MDL Number :
MFCD11976906
SMILES :
CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C

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Certificate of Analysis

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Tenovin-6 (CAS 1011557-82-6)  Product Citations

See how others have used Tenovin-6 (CAS 1011557-82-6). Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 26975631  Cheng, F. et al. 2016. Cancer letters. 375: 274-83.

PMID: # 25603536  Park, SY. et al. 2015. Biochimica et biophysica acta. 1853: 1060-72.

PMID: # 25119136  Chuang, HC. et al. 2014. PloS one. 9: e104821.

PMID: # 23892437  Hubbard, BP. et al. 2013. Cell cycle (Georgetown, Tex.). 12: 2233-40.

PMID: # 22207735  Yuan, H. et al. 2012. Blood. 119: 1904-1914.

PMID: # 22517433  van Leeuwen, IM. et al. 2012. Cell Cycle. 11: 1851-1861.

PMID: # 23029150  Lee, YL. et al. 2012. PloS one. 7: e45633.

PMID: # 28912678  Front Mol Neurosci. 271.

Citations 1 to 8 of 8 total
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Rated 5 out of 5 by from Van Leeuwen et al Van Leeuwen et al. (PubMed ID 22517433) used tenovin-6 to induce reversible cell cycle arrest in primary human fibroblasts and protect them from S- and M-phase poisons by activating p53. -SCBT Publication Review
Date published: 2015-03-30
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