Tenovin-6 is the water soluble analog of Tenovin-1 (sc-222342) and acts as a potent SIRT1 and SIRT2 inhibitor as well as p53 activator. SIRT1 and SIRT2 are protein-deacetylases that belong to the NAD+-dependent class III histone deacetylases. Although the function of sirtuins in humans is not entirely known, in yeast, they have been shown to regulate epigenetic gene expression. Studies show that tenovin-6 increases p53 levels more than tenovin-1 (sc-222342) and is also more toxic to yeast. Tenovin-6 has also been shown to inhibit SIRT3.
1. Brooks, C.L. and Gu, W. 2008. Cancer Cell. 13: 377-378. PMID: 18455119
2. Lain, S., et al. 2008. Cancer Cell. 13: 454-463. PMID: 18455128
3. Liu, T., et al. 2009. Cancer Res. 69: 1702-1705. PMID: 19244112
See how others have used Tenovin-6 (CAS 1011557-82-6). Click on the entry to view the PubMed entry .
PMID: # 26975631 Cheng, F. et al. 2016. Cancer letters. 375: 274-83.
PMID: # 25603536 Park, SY. et al. 2015. Biochimica et biophysica acta. 1853: 1060-72.
PMID: # 25119136 Chuang, HC. et al. 2014. PloS one. 9: e104821.
PMID: # 23892437 Hubbard, BP. et al. 2013. Cell cycle (Georgetown, Tex.). 12: 2233-40.
PMID: # 22207735 Yuan, H. et al. 2012. Blood. 119: 1904-1914.
PMID: # 22517433 van Leeuwen, IM. et al. 2012. Cell Cycle. 11: 1851-1861.
PMID: # 23029150 Lee, YL. et al. 2012. PloS one. 7: e45633.
PMID: # 28912678 Front Mol Neurosci. 271.
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