Molecular structure of Tenovin-1, CAS Number: 380315-80-0
Tenovin-1 (CAS 380315-80-0)
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Alternate Names:
N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
Application:
Tenovin-1 is an inhibitor of SIRT1 and SIRT2
CAS Number:
380315-80-0
Purity:
≥98%
Molecular Weight:
369.50
Molecular Formula:
C20H23N3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tenovin-1 is a compound that belongs to the class of Tenovins, and inhibits SIRT1 and SIRT2. SIRT1 and SIRT2 are protein-deacetylases and are members of the NAD+-dependent class III histone deacetylases. Tenovin-1 has been shown to activate and elevate acetylated p53 levels, induce apoptosis in vitro, and acetylate histone H4. Studies report that the water solubility of Tenovin-1 was increased by attaching a solubilizing group to the R2 position, creating a new Tenovin, Tenovin-6 (sc-224296).
Tenovin-1 (CAS 380315-80-0) References
- p53 Activation: a case against Sir. | Brooks, CL. and Gu, W. 2008. Cancer Cell. 13: 377-8. PMID: 18455119
- Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. | Lain, S., et al. 2008. Cancer Cell. 13: 454-63. PMID: 18455128
- The critical role of the class III histone deacetylase SIRT1 in cancer. | Liu, T., et al. 2009. Cancer Res. 69: 1702-5. PMID: 19244112
- p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors. | Sonnemann, J., et al. 2014. Br J Cancer. 110: 656-67. PMID: 24281001
- Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells. | Yoon, KB., et al. 2016. Immune Netw. 16: 183-8. PMID: 27340387
- The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line. | Marx, C., et al. 2018. Invest New Drugs. 36: 396-406. PMID: 29150734
- Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. | Bang, M., et al. 2019. Biomol Ther (Seoul). 27: 283-289. PMID: 30092626
- Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses. | Hackett, BA., et al. 2019. mBio. 10: PMID: 31289184
- Inverse regulation of claudin-2 and -7 expression by p53 and hepatocyte nuclear factor 4α in colonic MCE301 cells. | Hirota, C., et al. 2021. Tissue Barriers. 9: 1860409. PMID: 33356822
- How hydrophilic group affects drug-protein binding modes: Differences in interaction between sirtuins inhibitors Tenovin-1/Tenovin-6 and human serum albumin. | Gan, N., et al. 2021. J Pharm Biomed Anal. 201: 114121. PMID: 34020341
- Tenovin-1 inhibited dengue virus replication through SIRT2. | Wan, Y., et al. 2021. Eur J Pharmacol. 907: 174264. PMID: 34147476
- Tenovin-1 Ameliorates Renal Fibrosis in High-Fat-Diet-Induced Diabetic Nephropathy via Antioxidant and Anti-Inflammatory Pathways. | Kundu, A., et al. 2022. Antioxidants (Basel). 11: PMID: 36139886
- The propofol-induced mitochondrial damage in fetal rat hippocampal neurons via the AMPK/P53 signaling pathway. | Xiao, F., et al. 2022. Ann Transl Med. 10: 1106. PMID: 36388781
Inhibitor of:
SIRT1, and SIRT2.Activator of:
p21, and p53.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tenovin-1, 10 mg | sc-222342 | 10 mg | $89.00 |