SIRT1 Inhibitor IV, (S)-35 CAS: 848193-72-6
MF: C14H15ClN2O
MW: 262.73
An inhibitor of SIRT1.

SIRT1 Inhibitor IV, (S)-35 (CAS 848193-72-6)

SIRT1 Inhibitor IV, (S)-35 | CAS 848193-72-6 is rated 5.0 out of 5 by 1.
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Alternate Names: (6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxamide
Application: SIRT1 Inhibitor IV, (S)-35 is an inhibitor of SIRT1
CAS Number: 848193-72-6
Purity: ≥96%
Molecular Weight: 262.73
Molecular Formula: C14H15ClN2O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

SIRT 1 inhibitor IV, (S)-35 is a highly potent inhibitor of SIRT1 (IC50 = 38 nM). It is an entomerically pure compound that can permeate the cell and is metabolically stable. The inhibitor is similar in structure, potency (IC50 = 63 nM), and selectivity to SIRT1 inhibitor III. Sirt4-7 and class I/II HDAC are not inhibited by SIRT1 inhibitor (concentrations up to 100μM). Data shows that inhibition of SIRT1 by SIRT1 Inhibitor IV, (S)-35 enhances acetylation of p53 in response to DNA damaging agents.


References

1. Napper, A.D., et al. 2005. J. Med. Chem. 48: 8045-8054. PMID: 16335928
2. Porcu, M., et al. 2005. Trends Pharmacol. Sci. 26: 94-103. PMID: 15681027
3. Solomon, J.M., et al. 2006. Mol. Cell. Biol. 26: 28-38. PMID: 16354677

Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/mL), water (<2 mg/mL), and ethanol.
Storage :
Store at 4° C
Melting Point :
194.64° C (Predicted)
Boiling Point :
535.88° C at 760 mmHg (Predicted)
Density :
1.34 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
NAD-dependent deacetylase sirtuin 1: IC50 = 63 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
914268
MDL Number :
MFCD11045286
SMILES :
C1CCC2=C([[email protected]](C1)C(=O)N)NC3=C2C=C(C=C3)Cl

Download SDS (MSDS)

Certificate of Analysis

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SIRT1 Inhibitor IV, (S)-35 (CAS 848193-72-6)  Product Citations

See how others have used SIRT1 Inhibitor IV, (S)-35 (CAS 848193-72-6). Click on the entry to view the PubMed entry .

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PMID: # 23892437  Hubbard, BP. et al. 2013. Cell cycle (Georgetown, Tex.). 12: 2233-40.

Citations 1 to 1 of 1 total

Could you kindly let us know, how much concentration we need for this inhibitor to check the required inhibition of SIRT1 activity

Asked by: Biosensor
Thank you for your question. SIRT 1 inhibitor IV, (S)-35 is a highly potent inhibitor of SIRT1 (IC50 = 38 nM).
Answered by: Technical Support
Date published: 2017-09-27
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Rated 5 out of 5 by from Solomon Solomon, JM. et al. (PubMed 16354677) found that inhibition of SIRT1 via (S)-35, increased p53 acetylation but did not alter cell survival. -SCBT Publication Review
Date published: 2015-01-18
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