SIRT 1 inhibitor IV, (S)-35 is a highly potent inhibitor of SIRT1 (IC50 = 38 nM). It is an entomerically pure compound that can permeate the cell and is metabolically stable. The inhibitor is similar in structure, potency (IC50 = 63 nM), and selectivity to SIRT1 inhibitor III. Sirt4-7 and class I/II HDAC are not inhibited by SIRT1 inhibitor (concentrations up to 100μM). Data shows that inhibition of SIRT1 by SIRT1 Inhibitor IV, (S)-35 enhances acetylation of p53 in response to DNA damaging agents.
1. Napper, A.D., et al. 2005. J. Med. Chem. 48: 8045-8054. PMID: 16335928 2. Porcu, M., et al. 2005. Trends Pharmacol. Sci. 26: 94-103. PMID: 15681027 3. Solomon, J.M., et al. 2006. Mol. Cell. Biol. 26: 28-38. PMID: 16354677
Soluble in DMSO (>10 mg/mL), water (<2 mg/mL), and ethanol.
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