Molecular structure of SIRT1 Inhibitor IV, (S)-35, CAS Number: 848193-72-6
SIRT1 Inhibitor IV, (S)-35 (CAS 848193-72-6)
See product citations (4)
Alternate Names:
(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxamide
Application:
SIRT1 Inhibitor IV, (S)-35 is an inhibitor of SIRT1
CAS Number:
848193-72-6
Purity:
≥96%
Molecular Weight:
262.73
Molecular Formula:
C14H15ClN2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SIRT 1 inhibitor IV, (S)-35 is a sirtuin protein that has high potency and inhibits SIRT1 with IC50= 38 nM. It is an entomerically pure compound that can permeate the cell and is metabolically stable. The inhibitor is similar in structure, potency (IC50 = 63 nM), and as selective as SIRT1 inhibitor III. Sirt4-7 and class I/II HDAC (concentrations up to 100uM) are not inhibited by SIRT1 inhibitor. The inhibitor acts as a deacetylase and belongs to a new class of histone deacetylases (HDAC) that are involved in gene silencing. Data shows that inhibition of SIRT1 enhances acetylation of p53 in response to DNA damaging agents.
SIRT1 Inhibitor IV, (S)-35 (CAS 848193-72-6) References
- The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. | Porcu, M. and Chiarugi, A. 2005. Trends Pharmacol Sci. 26: 94-103. PMID: 15681027
- Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. | Napper, AD., et al. 2005. J Med Chem. 48: 8045-54. PMID: 16335928
- Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. | Solomon, JM., et al. 2006. Mol Cell Biol. 26: 28-38. PMID: 16354677
- The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration. | Saxena, M., et al. 2015. Oncogene. 34: 188-98. PMID: 24362520
Inhibitor of:
SIRT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SIRT1 Inhibitor IV, (S)-35, 500 µg | sc-204279 | 500 µg | $224.00 |