SIRT1 Antibody (B-7): sc-74465

SIRT1 Antibody (B-7) is a mouse monoclonal IgG1 kappa light chain antibody designed to recognize amino acids 448-747 of human SIRT1. SIRT1, also called SIR2, SIR2L1, and SIR2alpha, is a pivotal member of the sirtuin family, and functions as an NAD⁺-dependent deacetylase that plays a critical role in regulating various cellular processes, including transcriptional regulation, DNA damage repair, cell cycle progression, and aging. By deacetylating key substrates such as the tumor suppressor protein p53, SIRT1 modulates essential pathways involved in stress responses, metabolic control, and longevity, making SIRT1 a vital target for research into age-related diseases, cancer, and metabolic disorders. Anti-SIRT1 antibody (B-7) exhibits broad species reactivity, effectively detecting SIRT1 in mouse, rat, and human samples across multiple applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SIRT1 (B-7) antibody is available in both non-conjugated form and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatile options for diverse experimental setups. By enabling detailed investigation of SIRT1′s multifaceted roles in cellular physiology and pathology, SIRT1 monoclonal antibody (B-7) serves as an indispensable tool for researchers aiming to elucidate the mechanisms underlying critical biological processes and disease states.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SIRT1 Antibody (B-7) has 176 citations in a variety of scientific publications.

Primary antibodies like Anti-SIRT1 Antibody (B-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SIRT1 Antibody (B-7) Specifications

Alternate Product Name: SIRT1

Product Clone Name: B-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 448-747

Epitope Target: SIRT1

Epitope Species: human

Product Reactivity/Detection: SIRT1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 176 citations in various scientific publications

Available Conjugates/Forms for SIRT1 Antibody (B-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred SIRT1 antibody is SIRT1 Antibody (B-10): sc-74504.