Siglec-14 Inhibitors
Siglec-14 inhibitors are a class of chemical compounds that specifically target and inhibit the function of Siglec-14, a member of the sialic acid-binding immunoglobulin-like lectins (Siglec) family. Siglec-14 is primarily expressed on immune cells, particularly on macrophages and neutrophils, where it plays a role in modulating immune responses by recognizing sialic acid-containing ligands. Unlike inhibitory Siglecs, which transmit signals that dampen immune responses, Siglec-14 is an activating receptor. When it binds to its ligands, Siglec-14 triggers signaling pathways that lead to the activation of immune cells, promoting responses such as phagocytosis and the production of inflammatory mediators. Inhibitors of Siglec-14 work by preventing its interaction with sialylated ligands or by interfering with the receptor's ability to activate downstream signaling cascades.
The inhibition of Siglec-14 offers a valuable tool for studying immune regulation and the role of activating Siglecs in the immune system. By blocking Siglec-14, researchers can explore how the receptor contributes to immune cell activation, and how its inhibition affects processes like inflammation, pathogen recognition, and tissue homeostasis. Siglec-14 shares close structural similarities with other Siglecs, such as Siglec-5, and its inhibition helps differentiate the unique functions of each receptor. Studying Siglec-14 inhibitors provides insights into the broader network of sialic acid-mediated interactions within the immune system and how they influence cellular communication, immune modulation, and the balance between immune activation and inhibition. This research helps clarify the specific contributions of Siglec-14 to immune processes and its regulatory mechanisms in various biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This cytidine analog may induce hypomethylation of the Siglec-14 gene promoter, thereby decreasing its transcriptional activity and reducing protein expression levels. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2′-Deoxycytidine could lead to the demethylation of the Siglec-14 gene promoter, directly resulting in the downregulation of its mRNA and subsequent protein synthesis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
By inhibiting the NF-κB pathway, resveratrol may decrease the transcription of pro-inflammatory genes, including Siglec-14, leading to lower expression levels. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to downregulate transcription factors involved in inflammation, which could translate into decreased Siglec-14 expression on immune cells. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may downregulate Siglec-14 by binding to retinoic acid receptors, which then repress transcriptional activity at the gene's regulatory regions. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Through the inhibition of mTOR, rapamycin can suppress protein synthesis globally, which would include a decrease in the expression of Siglec-14. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane may repress the expression of Siglec-14 by altering histone acetylation states, leading to a more closed chromatin conformation at the gene locus. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
As a tyrosine kinase inhibitor, genistein has the potential to downregulate signal transduction pathways that lead to the expression of genes like Siglec-14. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin may reduce Siglec-14 protein levels by inhibiting kinases involved in the activation of transcription factors responsible for the gene's expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
By altering the activity of DNA methyltransferases and histone acetyltransferases, Epigallocatechin Gallate could lead to the downregulation of Siglec-14 mRNA and protein levels. | ||||||