SHPRH Activators
SHPRH activators encompass a group of chemical compounds that influence the functional activity of SHPRH, a protein implicated in DNA repair and genomic stability. Forskolin, by raising cAMP levels, activates PKA, potentially enhancing phosphorylation events that facilitate SHPRH in orchestrating DNA repair. Similarly, the tyrosine kinase inhibitor Genistein may enhance SHPRH's role by reducing competition in signaling pathways, allowing for a more pronounced engagement of SHPRH in the maintenance of genomic integrity. Sphingosine-1-phosphate operates through signaling pathways that respond to cellular stress, potentially bolstering SHPRH's involvement in DNA damage responses, while Thapsigargin, by disrupting calcium homeostasis, could indirectly promote the activity of SHPRH in response to genotoxic stress through calcium-dependent signaling mechanisms. PMA, as a PKC activator, and EGCG, with its kinase-inhibitory properties, may further potentiate SHPRH's role in DNA repair by modulating signal transduction and reducing negative regulation, respectively.
In addition, the PI3K inhibitors LY294002 and Wortmannin could shift cellular signaling in favor of SHPRH's DNA repair pathways, enhancing its functional activity. Inhibition of p38 MAPK by SB203580 and MEK by U0126 may also indirectly foster SHPRH's role in cellular stress responses, including DNA repair processes. A23187, through its calcium ionophore activity, raises intracellular calcium levels, which could augment SHPRH's role in genomic stability by triggering calcium-dependent signaling pathways. Staurosporine, despite its broad kinase inhibition profile, might selectively imptivate SHPRH by alleviating inhibitory pressures from specific kinases on SHPRH-associated pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular levels of cAMP. Elevated cAMP activates PKA, which can phosphorylate various substrates. This phosphorylation cascade can enhance the activity of SHPRH by promoting its role in DNA repair mechanisms. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein acts as a tyrosine kinase inhibitor, which can reduce competitive signaling pathways, thus potentially enhancing the functional activity of SHPRH in its genomic stability maintenance roles. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate interacts with its receptors to activate signaling pathways that are involved in cellular stress responses. This can lead to the activation of mechanisms where SHPRH is likely to be involved in DNA damage response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that raises intracellular calcium levels, which can activate calcium-dependent pathways, indirectly enhancing SHPRH's role in the response to genotoxic stress. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in signal transduction for cell cycle control, potentially enhancing SHPRH-mediated DNA repair pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits multiple kinases, potentially diminishing negative regulatory pathways and thereby enhancing the function of SHPRH in chromatin remodeling and DNA repair. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can shift cellular responses towards pathways that involve SHPRH, enhancing its activity in DNA repair and maintenance of genomic integrity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Similar to LY294002, Wortmannin is a PI3K inhibitor that may enhance SHPRH function by favoring the DNA repair pathways where SHPRH is active. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
By inhibiting p38 MAPK, SB203580 can modulate signaling pathways that influence cellular responses to DNA damage, potentially enhancing the activity of SHPRH in these pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as a calcium ionophore, raising intracellular calcium levels and potentially enhancing SHPRH activity by activating calcium-dependent signaling involved in genomic stability. | ||||||