SHPRH Inhibitors
Chemical inhibitors of SHPRH function primarily by intervening in the cellular mechanisms that are necessary for SHPRH to perform its role in DNA repair during the cell cycle. Alsterpaullone, Olomoucine, Roscovitine, NU2058, NU6027, AT7519, CR8, SNS-032, Dinaciclib, Flavopiridol, Milciclib, and R-roscovitine are compounds that inhibit cyclin-dependent kinases (CDKs), which are enzymes crucial for the progression and regulation of the cell cycle. Inhibiting these CDKs results in cell cycle arrest, thereby preventing SHPRH from executing its function in the DNA repair process which is typically activated during specific phases of the cell cycle. For instance, Alsterpaullone and NU2058 target CDKs, effectively causing a halt in the cell cycle at checkpoints where SHPRH operates, thus indirectly inhibiting the protein's activity. Olomoucine and its analog CR8, as well as the closely related R-roscovitine, all share the characteristic of selectively inhibiting CDK1, CDK2, and CDK5, which are kinases that must be active for the cell to progress past the G1/S and G2/M checkpoints, stages where SHPRH is known to be active in the repair of damaged DNA.
Furthermore, compounds such as SNS-032 and Flavopiridol exert their inhibitory action on a broader range of CDKs, including CDK7 and CDK9, which are also involved in transcription regulation that is essential for cell cycle progression. By inhibiting these kinases, these chemicals interfere with the phosphorylation events necessary for cell cycle continuation, which in turn indirectly impedes SHPRH function in DNA repair. Dinaciclib, with its potent CDK inhibitory activity, and Milciclib, targeting multiple kinases, enforce a broad-spectrum cell cycle blockade. This comprehensive inhibition of cell cycle kinases ensures that the cellular environment is not conducive for SHPRH to carry out its DNA repair responsibilities, as the protein's activity is closely linked to the cell cycle.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor that can inhibit CDKs which are necessary for cell cycle progression. SHPRH is involved in DNA repair during the cell cycle, and inhibition of CDKs by Alsterpaullone leads to cell cycle arrest, thereby functionally inhibiting SHPRH's role in DNA repair. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Olomoucine is another CDK inhibitor that selectively inhibits CDK1, CDK2, and CDK5. By inhibiting these kinases, Olomoucine prevents the cell cycle progression, indirectly inhibiting SHPRH's activity related to DNA repair mechanisms that are cell cycle-dependent. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine, also known as Seliciclib, is a purine analogue that inhibits multiple CDKs. It impedes the transition through the cell cycle, where SHPRH operates in the DNA repair pathway, thus indirectly inhibiting SHPRH's function in maintaining genome integrity. | ||||||
NU2058 | 161058-83-9 | sc-202744 sc-202744A | 5 mg 25 mg | $66.00 $321.00 | 2 | |
NU2058 is a guanine-based CDK inhibitor, principally targeting CDK2. By arresting the cell cycle, it indirectly inhibits SHPRH's associated DNA repair activities that are activated during specific phases of the cell cycle. | ||||||
NU6027 | 220036-08-8 | sc-215591 | 10 mg | $156.00 | 1 | |
NU6027 is a potent CDK inhibitor with preferential activity against CDK1 and CDK2. It hinders cell cycle progression, thereby inhibiting the role of SHPRH in the DNA repair process during the cell cycle. | ||||||
AT-7519 Hydrochloride | 902135-91-5 | sc-482715 | 5 mg | $125.00 | ||
AT7519 is a multi-CDK inhibitor that can block various CDKs involved in cell cycle regulation. By doing so, it indirectly inhibits SHPRH by preventing the cell cycle from proceeding to the stages where SHPRH is active in DNA repair. | ||||||
SNS-032 | 345627-80-7 | sc-364621 sc-364621A | 5 mg 10 mg | $169.00 $262.00 | ||
SNS-032 is a selective inhibitor of CDK2, CDK7, and CDK9. Inhibition of these kinases disrupts the normal progression of the cell cycle and thus indirectly inhibits the activity of SHPRH during the DNA repair phase. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $247.00 $888.00 | 1 | |
Dinaciclib is a strong inhibitor of several CDKs. By preventing the phosphorylation required for cell cycle progression, Dinaciclib indirectly inhibits the function of SHPRH in the process of DNA repair. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol strongly inhibits various CDKs and can cause cell cycle arrest. This inhibition indirectly affects SHPRH's role in the DNA repair mechanisms that are tightly coupled with the cell cycle. | ||||||
PHA-848125 | 802539-81-7 | sc-364581 sc-364581A | 5 mg 10 mg | $304.00 $555.00 | ||
Milciclib is a multi-kinase inhibitor with activity against various CDKs. By halting the cell cycle, Milciclib indirectly inhibits SHPRH's function in DNA repair during the cell cycle. | ||||||