Molecular structure of PHA-848125, CAS Number: 802539-81-7
PHA-848125 (CAS 802539-81-7)
Application:
PHA-848125 is a potent, ATP-competitive Cdk2/cyclin A and Trk A inhibitor
CAS Number:
802539-81-7
Molecular Weight:
460.57
Molecular Formula:
C25H32N8O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PHA-848125 is a potent, ATP-competitive Cdk2/cyclin A inhibitor (IC50 = 45 nM). PHA-848125 also inhibits additional cdk proteins, but to significantly lesser extent; the activities of Cdk7/cyclin H (IC50 = 0.15 µM), Cdk4/cyclin D1 (IC50 = .0.16 µM), Cdk5/p35 (IC50 = 0.265 µM), as well as Cdk2/cyclin E (IC50 = 0.363 µM) and Cdk1/cyclin B (IC50 = 0.398 µM). Trk A (NTRK1) is also inhibited by PHA-848125 with similar potency to the Cdk′s. PHA-848125 also impairs phosphorylation of the retinoblastoma (Rb) protein at Cdk2 and Cdk4 specific sites, reduces retinoblastoma protein and cyclin A levels, and increases p21(Cip1), p27(Kip1) and p53 expression.
Inhibitor of:
4933411G11Rik, ALS2CR7, ARHGAP (Rho GTPase activating protein), ARHGEF18, ARHGEF3, BEND6, Beta-NAP, C12orf63, C6orf1, C9orf100, CCNI2, Cdc7, Cdk, CDK5RAP, CdkL4, Cdx2, CNTD1, cyclin δ-1, cyclin B, cyclin F, cyclin YL1, cyclin YL3, D-type cyclin, D14Ertd449e, Dcpp2, DENND2D, DOC1, E2F-8, FAM111B, FAM127B, FAM160A1, FLJ32549, GEMC1, Gm75, GMD, GPN3, Gtlf3b, HST, KBP, KKIALRE, LIN-52, LIN37, LOC643909, MPc3_CBX8, Nim1, OTTMUSG00000016588, p18, p35, p39 (CDK5R), PCTAIRE-2, Peregrin, Pho85, POGZ, PREI4, Repetin, rhophilin, SERTAD4, SHPRH, Speedy A, Speedy E6, TCHHL1, TEX27, TMEM194, V1RG1, WDR66, ZHX3, ZNF705A, and ZSCAN16.Activator of:
Cables1, CCRK, Cdk10, CDK2AP1, Cig2, Clb2, and cyclin YL3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PHA-848125, 5 mg | sc-364581 | 5 mg | $304.00 | |||
PHA-848125, 10 mg | sc-364581A | 10 mg | $555.00 |