Shank 2 Inhibitors
Shank 2 inhibitors represent a diverse and intricate group of compounds, each with specific mechanisms of action that intricately modulate the function of this crucial protein. One such inhibitor is Iodoacetic Acid, which disrupts glycolysis, thereby indirectly influencing Shank 2 by altering the cellular energy status. This alteration in energy dynamics has downstream effects on Shank 2, showcasing the interconnectedness of cellular processes. Thapsigargin, another inhibitor, interferes with calcium homeostasis, impacting Shank 2 through its involvement in calcium-dependent signaling pathways. The disruption of calcium balance directly influences Shank 2 function, emphasizing the pivotal role of intracellular signaling in regulating its activity. Compounds like KN-93 and FK506 target specific components of calcium signaling pathways, namely CaMKII and calcineurin, respectively. Their effects reverberate through the intricate network of calcium-related events linked to Shank 2 function.
Similarly, KN-62 inhibits CaMKIV, disrupting calcium-dependent processes associated with synaptic plasticity and, consequently, influencing Shank 2. Nifedipine, Cyclosporin A, and 2-AEDB, while not directly targeting Shank 2, impact calcium-related processes, indirectly modulating Shank 2 function through their influence on broader cellular pathways. Ro 31-8220, by inhibiting PKC, alters cellular processes, including synaptic plasticity, indirectly impacting Shank 2. Ryanodine, through modulation of RyRs, affects calcium release, thereby influencing Shank 2 through its association with calcium-dependent events. ML-7 inhibits MLCK, impacting cytoskeletal dynamics and synaptic plasticity, showcasing yet another indirect pathway through which Shank 2 function can be influenced. PD98059 disrupts the MAPK pathway, altering cellular processes related to synaptic plasticity and indirectly modulating Shank 2. This extensive array of inhibitors highlights the sophisticated and interconnected cellular pathways that can be strategically harnessed to modulate Shank 2 function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Iodoacetic acid | 64-69-7 | sc-215183 sc-215183A | 10 g 25 g | $57.00 $99.00 | ||
Iodoacetic Acid is an alkylating agent that inhibits enzymes involved in glycolysis, disrupting cellular energy metabolism. Its interference with glycolysis indirectly influences Shank 2, as the protein is linked to synaptic plasticity and may be modulated by alterations in cellular energy status. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a selective inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump, leading to calcium release from the endoplasmic reticulum. The disruption of calcium homeostasis by Thapsigargin indirectly influences Shank 2, which is implicated in calcium-dependent signaling pathways regulating synaptic function. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is a specific inhibitor of calmodulin-dependent protein kinase II (CaMKII). By targeting CaMKII, KN-93 modulates calcium signaling pathways linked to Shank 2 function. The inhibition of CaMKII can indirectly impact Shank 2 by altering the phosphorylation status and downstream signaling events associated with synaptic plasticity. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 is an immunosuppressive drug that inhibits calcineurin, a calcium-dependent phosphatase. Its interference with calcineurin signaling indirectly influences Shank 2, as calcineurin is involved in the regulation of synaptic plasticity. The modulation of this pathway by FK506 can impact Shank 2 function and downstream cellular processes. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $136.00 | 20 | |
KN-62 is a selective inhibitor of calmodulin-dependent protein kinase IV (CaMKIV). Its action on CaMKIV disrupts calcium-dependent signaling pathways associated with synaptic plasticity, indirectly influencing Shank 2 function. The inhibition of CaMKIV by KN-62 alters downstream events linked to Shank 2, impacting its role in cellular processes. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker that inhibits L-type calcium channels. By blocking calcium influx, Nifedipine disrupts calcium-dependent processes associated with synaptic function. Its indirect impact on calcium signaling pathways can influence Shank 2, which is intricately connected to calcium-regulated events in neuronal cells. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A inhibits calcineurin, a calcium-dependent phosphatase. Its interference with calcineurin signaling has downstream effects on synaptic plasticity-related pathways, indirectly influencing Shank 2. The modulation of calcineurin by Cyclosporin A alters cellular events linked to Shank 2 function and synaptic plasticity. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-Aminoethoxydiphenyl Borate (2-AEDB) is an inhibitor of inositol trisphosphate receptors (IP3Rs), disrupting calcium release from the endoplasmic reticulum. Its interference with calcium homeostasis indirectly influences Shank 2, which is implicated in calcium-dependent signaling pathways regulating synaptic function and plasticity. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Ro 31-8220 is a potent inhibitor of protein kinase C (PKC). Its action on PKC signaling pathways can indirectly modulate Shank 2, as PKC is involved in various cellular processes, including synaptic plasticity. The inhibition of PKC by Ro 31-8220 alters downstream events associated with Shank 2 function and its regulatory role in neuronal cells. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine is an activator of ryanodine receptors (RyRs) at low concentrations but inhibits RyRs at higher concentrations. Its modulation of RyRs influences calcium release from the endoplasmic reticulum, indirectly impacting Shank 2, which is associated with calcium-dependent events in synaptic function and plasticity. | ||||||