Shank 2 Activators
The chemical class of Shank 2 activators encompasses a diverse array of compounds with distinct mechanisms of action, each influencing synaptic function and plasticity. Aniracetam, a nootropic, modulates glutamate receptors, indirectly impacting Shank 2 activation and synaptic plasticity. A769662 activates AMPK, linking cellular energy homeostasis to Shank 2-regulated pathways, potentially influencing synaptic function through energy-related processes. Rolipram, a PDE4 inhibitor, elevates cAMP levels, indirectly affecting Shank 2 activation and synaptic plasticity. Icilin, a TRPM8 channel agonist, modulates calcium signaling, contributing to Shank 2-associated pathways and potential synaptic regulation. Y-27632, a ROCK inhibitor, influences cytoskeletal dynamics, indirectly participating in Shank 2 activation and synaptic morphology.
Zaprinast, a phosphodiesterase inhibitor, elevates cGMP levels, impacting pathways related to Shank 2 activation and synaptic plasticity. BDNF, while not a chemical, exerts neurotrophic effects, indirectly influencing Shank 2-associated pathways and contributing to synaptic function. Talampanel, an AMPA receptor antagonist, modulates glutamate signaling, potentially affecting Shank 2 activation and synaptic plasticity through glutamatergic neurotransmission. Go6976, a PKC inhibitor, modulates intracellular signaling, indirectly influencing Shank 2 activation and potential synaptic regulation. CGP 57380, a p38 MAPK inhibitor, impacts MAPK signaling, contributing to Shank 2-associated pathways and potential synaptic plasticity regulation. Riluzole modulates glutamate release, indirectly affecting Shank 2 activation and synaptic plasticity through the regulation of glutamatergic neurotransmission. Bisindolylmaleimide I, a PKC inhibitor, influences PKC-mediated signaling, linking to Shank 2 activation and potential synaptic regulation. This diverse group of chemical modulators provides researchers with a versatile toolkit to explore the intricate regulation of Shank 2 and its role in synaptic function and plasticity across various cellular contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aniracetam | 72432-10-1 | sc-203514 sc-203514A | 50 mg 250 mg | $115.00 $456.00 | ||
Aniracetam, a nootropic compound, modulates glutamate receptors and enhances synaptic plasticity. Through the regulation of glutamate receptors, Aniracetam indirectly influences the signaling pathways associated with Shank 2 activation, promoting synaptic function and plasticity. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662 activates AMP-activated protein kinase (AMPK), a crucial regulator of cellular energy homeostasis. By influencing AMPK activity, A769662 indirectly impacts cellular processes that may contribute to Shank 2 activation, suggesting a role in modulating synaptic function through energy-related pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor that increases cAMP levels. Through the elevation of cAMP, Rolipram indirectly affects intracellular signaling pathways related to Shank 2 activation, potentially influencing synaptic plasticity and function. | ||||||
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $91.00 $257.00 | 9 | |
Icilin is a TRPM8 channel agonist, influencing calcium signaling. By activating TRPM8, Icilin indirectly modulates intracellular calcium levels, affecting pathways associated with Shank 2 activation and potentially contributing to synaptic regulation and plasticity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), impacting cytoskeletal dynamics. By inhibiting ROCK, Y-27632 indirectly influences cellular processes linked to Shank 2 activation, potentially participating in the regulation of synaptic morphology and function through cytoskeletal modulation. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast is a phosphodiesterase inhibitor that elevates cGMP levels. Through the modulation of cGMP signaling, Zaprinast indirectly influences pathways related to Shank 2 activation, potentially affecting synaptic plasticity and function through cGMP-mediated signaling cascades. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Go6976 is a selective protein kinase C (PKC) inhibitor, impacting intracellular signaling. Through the inhibition of PKC, Go6976 indirectly influences cellular processes associated with Shank 2 activation, suggesting a role in modulating synaptic function and plasticity through PKC-mediated signaling pathways. | ||||||
CGP 57380 | 522629-08-9 | sc-202993 | 5 mg | $172.00 | 6 | |
CGP 57380 is a selective inhibitor of p38 mitogen-activated protein kinase (MAPK), influencing MAPK signaling. By inhibiting p38 MAPK, CGP 57380 indirectly modulates pathways related to Shank 2 activation, potentially contributing to the regulation of synaptic function and plasticity through the modulation of intracellular signaling cascades. | ||||||
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $193.00 $213.00 $317.00 | 1 | |
Riluzole modulates glutamate signaling by inhibiting glutamate release. Through the regulation of glutamate levels, Riluzole indirectly influences pathways associated with Shank 2 activation, potentially impacting synaptic function and plasticity through the modulation of glutamatergic neurotransmission. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a selective inhibitor of protein kinase C (PKC), influencing PKC-mediated signaling. Through PKC inhibition, Bisindolylmaleimide I indirectly modulates cellular processes associated with Shank 2 activation, suggesting a role in the regulation of synaptic function and plasticity through PKC-dependent signaling pathways. | ||||||