Molecular structure of Aniracetam, CAS Number: 72432-10-1
Aniracetam (CAS 72432-10-1)
Alternate Names:
1-(4-Methoxybenzoyl)-2-pyrrolidinone
Application:
Aniracetam is a nootropic agent with modulatory actions at Glutamate and AMPA receptors demonstrating anxiolytic activity
CAS Number:
72432-10-1
Purity:
≥99%
Molecular Weight:
219.24
Molecular Formula:
C12H13NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Technical Information
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SDS & Certificate of Analysis
Aniracetam has modulatory actions through allosteric potentiation of reduction of glutamate receptor desensitization, AMPA specific receptors, and potentiation of metabotropic glutamate receptor activity. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
Aniracetam (CAS 72432-10-1) References
- Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. | Nakamura, K. and Kurasawa, M. 2001. Eur J Pharmacol. 420: 33-43. PMID: 11412837
- Aniracetam: its novel therapeutic potential in cerebral dysfunctional disorders based on recent pharmacological discoveries. | Nakamura, K. 2002. CNS Drug Rev. 8: 70-89. PMID: 12070527
- Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus. | Isaacson, JS. and Nicoll, RA. 1991. Proc Natl Acad Sci U S A. 88: 10936-40. PMID: 1660156
- Aniracetam improves behavioural responses and facilitates signal transduction in the rat brain. | Ventra, C., et al. 1994. J Psychopharmacol. 8: 109-17. PMID: 22298538
- Aniracetam does not alter cognitive and affective behavior in adult C57BL/6J mice. | Elston, TW., et al. 2014. PLoS One. 9: e104443. PMID: 25099639
- Designing a Formulation of the Nootropic Drug Aniracetam Using 2-Hydroxypropyl-β-Cyclodextrin Suitable for Parenteral Administration. | Goldsmith, SD. and McDowell, A. 2018. Pharmaceutics. 10: PMID: 30453664
- Aniracetam does not improve working memory in neurologically healthy pigeons. | Phillips, H., et al. 2019. PLoS One. 14: e0215612. PMID: 31002681
- AMPA receptor modulation through sequential treatment with perampanel and aniracetam mitigates post-stroke damage in experimental model of ischemic stroke. | Sharma, H., et al. 2023. Naunyn Schmiedebergs Arch Pharmacol. 396: 3529-3545. PMID: 37231168
- Aniracetam. An overview of its pharmacodynamic and pharmacokinetic properties, and a review of its therapeutic potential in senile cognitive disorders. | Lee, CR. and Benfield, P. 1994. Drugs Aging. 4: 257-73. PMID: 8199398
- Treatment of insomnia by concomitant therapy with Zopiclone and Aniracetam in patients with cerebral infarction, cerebroatrophy, Alzheimer's disease and Parkinson's disease. | Katsunuma, H., et al. 1998. Psychiatry Clin Neurosci. 52: 198-200. PMID: 9628149
Inhibitor of:
AMPA 3, CNIH3, and NGL-1.Activator of:
AMPA 1, AMPA 2, AMPA 3, AMPA 4, CAPS1, CNIH2, EG632778, GluR-1, GluR-2, GRIP2, GSG1L, LRFN3, LRRTM1, LRRTM2, NETO1, Neuritin, NGF, P/Q-type Ca++ CP α1A, SAPAP2, Serine racemase, SEZ6L, Shank 1, Shank 2, SHISA8, SHISA9, SLITRK5, and Synapsin Ia/b.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aniracetam, 50 mg | sc-203514 | 50 mg | $115.00 | |||
Aniracetam, 250 mg | sc-203514A | 250 mg | $456.00 |