SART-3 Activators
Chemical activators of SART-3 engage with the protein in various ways to enhance its activity related to RNA splicing. Resveratrol is known to activate sirtuin pathways such as SIRT1, which interacts with SART-3 to augment its deacetylase activity, thereby promoting its role in cellular stress responses. Similarly, spermidine can lead to the induction of autophagy, and through the inhibition of the acetyltransferase EP300, it can contribute to the functional enhancement of SART-3 by ensuring the recycling of spliceosomal components. Trichostatin A, as a histone deacetylase inhibitor, facilitates a relaxed chromatin state that provides splicing factors, including SART-3, with improved access to DNA for processing mRNA.
Furthermore, 5-Azacytidine's inhibition of DNA methyltransferases results in DNA hypomethylation, which may lead to the upregulation of genes that are involved in spliceosome assembly, thus fostering SART-3's role in RNA splicing. An analogous effect is seen with sodium butyrate, another histone deacetylase inhibitor, which increases chromatin accessibility and may enhance the activity of SART-3. In the context of protein degradation, MG132, a proteasome inhibitor, and disulfiram, which also inhibits the proteasome, can elevate the levels of snRNP components available for SART-3 action. Moreover, Leptomycin B, which inhibits protein export from the nucleus, increases the concentration of nuclear splicing factors and snRNPs, thereby augmenting SART-3's function. SAHA, similar to other histone deacetylase inhibitors, increases chromatin accessibility, which can lead to enhanced SART-3 activity. Chloroquine's inhibition of autophagy can indirectly increase the activity of SART-3 by causing an accumulation of cellular components like snRNPs. Lastly, beta-lapachone activates NQO1, which may influence SART-3's activity by altering the redox-sensitive cellular processes it is involved in.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin pathways, which includes SIRT1. SIRT1 has been shown to interact with SART-3, enhancing its deacetylase activity and thus its functional activation in cellular stress response. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine is known to induce autophagy through inhibition of the acetyltransferase EP300. SART-3, being associated with spliceosomal snRNP assembly, may have increased activity as autophagy processes can recycle snRNP components, potentially enhancing SART-3 function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can lead to a relaxed chromatin structure. This relaxation allows enhanced access for splicing factors and components, including SART-3, facilitating its function in mRNA processing. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, leading to hypomethylation of DNA and possibly increased transcription of genes involved in spliceosome assembly and function, thereby potentially enhancing the activity of SART-3 in RNA splicing. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide functions as a sirtuin inhibitor, specifically inhibiting SIRT1. Inhibition of SIRT1 can result in increased acetylation of proteins involved in RNA processing, which may indirectly enhance the functional activity of SART-3 in snRNP assembly. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to the accumulation of proteins within the cell. By inhibiting protein degradation, it may indirectly increase the functional activity of SART-3 by increasing the availability of snRNP components for splicing. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B inhibits the export of proteins from the nucleus. As SART-3 is involved in the nuclear retention of snRNPs, this chemical can enhance the activity of SART-3 by increasing the nuclear concentration of splicing factors and snRNPs. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate acts as a histone deacetylase inhibitor, which can result in a more accessible chromatin structure and potentially an increase in the activity of SART-3, as it may allow greater assembly and function of spliceosomal components. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine inhibits autophagy by preventing lysosomal acidification. This can lead to an accumulation of cellular components, including snRNPs, which could indirectly increase the activity of SART-3 in snRNP processing and assembly. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is a histone deacetylase inhibitor that can enhance chromatin accessibility for splicing factors. This can lead to an increased activity of SART-3, as it may promote the assembly and function of spliceosomal components. | ||||||