RNF4 Activators
The chemical class of RNF4 activators mainly comprises compounds that indirectly influence RNF4 through modulation of ubiquitination and sumoylation pathways. Proteasome inhibitors like MG132, Lactacystin, Bortezomib, and Velcade play a crucial role in this class. By inhibiting the proteasome, these compounds can indirectly affect the ubiquitin-protein ligase activity of RNF4, altering the degradation of proteins targeted by RNF4 for ubiquitination.Inhibitors of SUMOylation, such as ML792, Ginkgolic Acid, and Anacardic Acid, are also significant. These compounds inhibit the SUMO-conjugating enzymes, potentially impacting the substrates and activity of RNF4 in sumoylation-dependent processes.
Additionally, this class includes compounds like Pyr41, a ubiquitin E1 inhibitor, and Withaferin A, known to modulate ubiquitination processes. These compounds can indirectly influence RNF4's role in ubiquitin-mediated protein degradation. Nutlin-3 and Thalidomide are included due to their effects on protein degradation pathways and immunomodulatory effects, which could intersect with the regulatory functions of RNF4. Curcumin, known for its wide-ranging biological activities, is part of this class due to its potential impact on both ubiquitination and sumoylation pathways, which are key to RNF4's function.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor, potentially affecting RNF4's role in protein degradation through ubiquitination. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Another proteasome inhibitor, might indirectly influence RNF4's ubiquitin-protein ligase activity. | ||||||
ML-792 | 1644342-14-2 | sc-507423 | 10 mg | $390.00 | ||
A selective inhibitor of SUMO-activating enzyme (SAE), could indirectly affect RNF4's sumoylation targets. | ||||||
(−)Epicatechin | 490-46-0 | sc-205672 sc-205672A | 1 mg 5 mg | $50.00 $135.00 | ||
Known to inhibit SUMOylation, potentially impacting RNF4's function in sumoylation-dependent pathways. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
A SUMOylation inhibitor, may indirectly influence the substrates and activity of RNF4. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
A selective ubiquitin E1 inhibitor, could indirectly affect processes regulated by RNF4. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Disrupts MDM2-p53 interaction, influencing ubiquitin-mediated degradation pathways relevant to RNF4. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
A steroidal lactone that can modulate ubiquitination processes, potentially influencing RNF4 activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor, may affect the degradation pathway involving RNF4. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Modulates protein degradation and has immunomodulatory effects, potentially impacting RNF4. | ||||||