Rlf Activators
Chemical activators of the Rearranged L-myc fusion protein engage in various biochemical interactions to facilitate its activation. Forskolin, through its direct stimulation of adenylyl cyclase, leads to a surge in cAMP levels, which in turn activates protein kinase A (PKA). PKA is a pivotal kinase that, upon activation, phosphorylates target proteins, including the Rearranged L-myc fusion protein, thereby modulating its activity. Similarly, Dibutyryl-cAMP, a synthetic analog of cAMP, permeates cellular membranes and activates PKA, following the same pathway towards the activation of the protein.
Complementing these mechanisms, PMA and TPA activate protein kinase C (PKC), which phosphorylates substrates that can lead to the activation of the Rearranged L-myc fusion protein. Ionomycin and FPL-64176 increase intracellular calcium levels, which subsequently activate calcium-dependent protein kinases that can phosphorylate and activate the Rearranged L-myc fusion protein. A23187, also known as Calcimycin, functions as a calcium ionophore, similarly elevating calcium levels within the cell to induce activation of calcium-dependent signaling pathways. Calyculin A and Okadaic Acid, both inhibitors of protein phosphatases, lead to an increase in phosphorylated proteins, which includes the activation state of the Rearranged L-myc fusion protein. Thapsigargin contributes to this process by inhibiting SERCA, causing an increase in cytosolic calcium and activating calcium-mediated signaling pathways. Lastly, Bisindolylmaleimide I, while primarily a PKC inhibitor, can under certain conditions also serve as an activator, thus contributing to the phosphorylation cascade that affects the Rearranged L-myc fusion protein. Each of these chemicals, through their distinct mechanisms of action, can initiate a series of phosphorylation events that facilitate the activation of the Rearranged L-myc fusion protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate and thereby activate proteins involved in the signaling pathways that include the Rearranged L-myc fusion gene protein. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate substrates involved in the same signaling pathway as the Rearranged L-myc fusion gene protein, leading to its activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore, elevating intracellular calcium levels, which can activate calcium-dependent protein kinases that phosphorylate and activate the Rearranged L-myc fusion gene protein. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA, potentially resulting in the phosphorylation and activation of targets within the Rearranged L-myc fusion gene protein's signaling pathway. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is known to activate JNK and p38 MAP kinase pathways, which can lead to activation of transcription factors and proteins that are part of the signaling cascade involving the Rearranged L-myc fusion gene protein. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation and consequent activation of proteins in pathways that include the Rearranged L-myc fusion gene protein. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits protein phosphatases, resulting in the accumulation of phosphorylated proteins, which can activate pathways involving the Rearranged L-myc fusion gene protein. | ||||||
FPL-64176 | 120934-96-5 | sc-201491 | 5 mg | $81.00 | 1 | |
FPL-64176 is a calcium channel activator that increases intracellular calcium levels, which can activate calcium-dependent kinases, potentially resulting in the activation of the Rearranged L-myc fusion gene protein. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as an ionophore for divalent cations, particularly calcium, thereby increasing the intracellular calcium concentration and activating calcium-dependent signaling pathways, which could lead to the activation of the Rearranged L-myc fusion gene protein. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to a rise in cytosolic calcium levels, which activates calcium-dependent signaling pathways that can result in the activation of the Rearranged L-myc fusion gene protein. | ||||||