REEP4 Activators
REEP4, known as Receptor Accessory Protein 4, is a member of the REEP (Receptor Expression Enhancing Protein) family, which is implicated in shaping and remodeling the endoplasmic reticulum (ER) membrane network. The REEP proteins are involved in various cellular processes, including the regulation of ER structure, modulation of receptor trafficking, and possibly the maintenance of cellular lipid homeostasis.REEP4 specifically has been shown to influence the morphology of the ER, promoting the formation of tubular ER structures. The protein contains hydrophobic hairpin domains that embed in the ER membrane and contribute to membrane curvature. In doing so, REEP4 plays a role in the proper functioning of the ER, which is essential for protein folding, lipid synthesis, and calcium storage.
Expression of REEP4 has been linked to certain types of cancer, suggesting it may have a role in tumor biology, potentially through its effects on ER stress responses or cellular metabolism. The overexpression of REEP4 has been associated with alterations in ER structure and function, which can influence cell proliferation and survival, key factors in cancer progression.Within the nervous system, REEP4 may be involved in the development and maintenance of neuronal processes. Its presence in the ER of axons and dendrites suggests a role in neural plasticity, possibly by modulating the trafficking of membrane proteins and receptors that are critical for synaptic function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises cAMP levels, which can enhance protein kinase A (PKA) activity. PKA phosphorylation may affect proteins like REEP4 that are involved in cellular transport. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase-4, increasing cAMP levels and activating PKA. PKA can potentially phosphorylate REEP4, affecting its function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, leading to increased cAMP and activated PKA. This can hypothetically affect pathways involving REEP4. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits certain protein kinases, potentially altering signaling pathways that may indirectly enhance the functional activity of REEP4. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates various signaling pathways and could affect those pathways indirectly associated with REEP4 function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates sirtuins and AMPK, which may influence cellular pathways that indirectly involve REEP4's role in the endoplasmic reticulum. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which might affect proteins associated with the endoplasmic reticulum structure, such as REEP4. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, potentially influencing calcium-dependent signaling pathways that can indirectly affect REEP4. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, stressing the ER and potentially affecting ER-associated proteins like REEP4. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts ER calcium stores, leading to a stress response that could potentially enhance the activity of ER-associated proteins like REEP4. | ||||||