REEP4 Activators

REEP4, known as Receptor Accessory Protein 4, is a member of the REEP (Receptor Expression Enhancing Protein) family, which is implicated in shaping and remodeling the endoplasmic reticulum (ER) membrane network. The REEP proteins are involved in various cellular processes, including the regulation of ER structure, modulation of receptor trafficking, and possibly the maintenance of cellular lipid homeostasis.REEP4 specifically has been shown to influence the morphology of the ER, promoting the formation of tubular ER structures. The protein contains hydrophobic hairpin domains that embed in the ER membrane and contribute to membrane curvature. In doing so, REEP4 plays a role in the proper functioning of the ER, which is essential for protein folding, lipid synthesis, and calcium storage.

Expression of REEP4 has been linked to certain types of cancer, suggesting it may have a role in tumor biology, potentially through its effects on ER stress responses or cellular metabolism. The overexpression of REEP4 has been associated with alterations in ER structure and function, which can influence cell proliferation and survival, key factors in cancer progression.Within the nervous system, REEP4 may be involved in the development and maintenance of neuronal processes. Its presence in the ER of axons and dendrites suggests a role in neural plasticity, possibly by modulating the trafficking of membrane proteins and receptors that are critical for synaptic function.