You may not log in without verifying your email address.
Please check your email (including your spam email) for the Welcome message that was sent.
Sodium phenylbutyrate, an HDAC (histone deacetylase) inhibitor, has been shown to cause cellular differentiation, growth arrest, and apoptosis in certain cells. Sodium phenylbutyrate has been reported to cause cell growth arrest at the G1 phase and induce apoptosis through activation of JNK. Studies suggest that Sodium Phenylbutyrate also acts as a chemical chaperone by causing a reduction of the load of mutant and mislocated proteins retained in the endoplasmic reticulum (ER). Other experiments have noted that Sodium Phenylbutyrate demonstrates neuroprotective capabilities by attenuating infarction volume, apoptosis, hemispheric swelling and improving neurological status in a murine model of hypoxia-ischemia. Moreover, this agent has been shown to suppress ER-mediated apoptosis by initiating factor 2α phosphorylation, caspase-12 activation, and CCAAT/enhancer-binding protein homologous protein induction.
1. Appelskog, I.B., et al. 2004. Int. J. Oncol. 24: 1419-1425. PMID: 15138583
2. Zhang, X., et al. 2004. J. Cell. Biochem. 93: 819-829. PMID: 15389886
3. Qi, X., et al. 2004. Mol. Pharmacol. 66: 899-908. PMID: 15226415
4. Gardian, G., et al. 2005. J. Biol. Chem. 280: 556-563. PMID: 15494404
See how others have used Sodium phenylbutyrate. Click on the entry to view the PubMed entry .
PMID: # 31320609 Qiu, Y. et al. 2019. Cell Death Dis. 10: 547.
PMID: # 29080681 Yang, F.|Yang, L.|Wataya-Kaneda, M.|Yoshimura, T.|Tanemura, A.|Katayama, I.| et al. 2018. J. Invest. Dermatol. 138: 669-678.
PMID: # 30100737 Chen, J. et al. 2018. Onco Targets Ther. 11: 4315-4325.
PMID: # 30224704 Ingles, J.|Simpson, A.|Kyathanahalli, C.|Anamthathmakula, P.|Hassan, S.|Jeyasuria, P.|Condon, JC.| et al. 2018. Cell Death Dis. 9: 933.
PMID: # 28316566 Huang, L.|Xue, Y.|Feng, D.|Yang, R.|Nie, T.|Zhu, G.|Tao, K.|Gao, G.|Yang, Q.| et al. 2017. Front Cell Neurosci. 11: 52.
PMID: # 28444766 Zhu, G.|Tao, L.|Wang, R.|Xue, Y.|Wang, X.|Yang, S.|Sun, X.|Gao, G.|Mao, Z.|Yang, Q.| et al. 2017. J. Neurochem. 142: 272-285.
PMID: # 29235576 Eigner, K.|Filik, Y.|Mark, F.|Schütz, B.|Klambauer, G.|Moriggl, R.|Hengstschläger, M.|Stangl, H.|Mikula, M.|Röhrl, C.| et al. 2017. Sci Rep. 7: 17498.
PMID: # 27341688 Sanda, GM.|Deleanu, M.|Toma, L.|Stancu, CS.|Simionescu, M.|Sima, AV.| et al. 2017. J. Cell. Biochem. 118: 661-669.
PMID: # 26762342 Tao, K. et al. 2016. Neuroscience bulletin. 32: 61-9.
PMID: # 26907328 Zhou, Y. et al. 2016. Viruses. 8:
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.