Ran Inhibitors
Ran inhibitors represent a class of chemical compounds that specifically target and disrupt the activity of the Ran GTPase protein, which plays a crucial role in nucleocytoplasmic transport within eukaryotic cells. These inhibitors are designed to modulate the function of Ran by interfering with its ability to hydrolyze GTP (guanosine triphosphate), which is essential for regulating the transport of macromolecules such as proteins and RNA between the cell nucleus and cytoplasm. Ran itself acts as a molecular switch, alternating between an active GTP-bound state and an inactive GDP-bound state, controlling the directionality and efficiency of nucleocytoplasmic transport. Ran inhibitors exert their effects by perturbing this nucleotide cycling and thus impeding the normal functioning of the Ran GTPase.
The structural diversity of Ran inhibitors varies widely, encompassing small molecules, peptides, and even antibodies, each with distinct mechanisms of action. These compounds often bind to specific regions of Ran or its regulatory proteins, disrupting the intricate choreography of nucleocytoplasmic transport. Some Ran inhibitors may competitively inhibit the binding of GTP to Ran, locking it in an inactive GDP-bound state. Others might interfere with the interactions between Ran and its cofactors, preventing the formation of essential transport complexes. By targeting Ran, these inhibitors have the ability to reveal fundamental insights into cellular processes related to nuclear import and exports.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Leptomycin B specifically inhibits CRM1/exportin 1, a key nuclear export receptor that interacts with Ran. By inhibiting CRM1, Leptomycin B disrupts the normal export of proteins and RNA from the nucleus, which can indirectly influence Ran expression and function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts protein transport by inhibiting the exchange of GDP for GTP on ARF proteins, indirectly affecting the localization and function of various proteins, including Ran. This disruption can lead to alterations in cell cycle progression and nuclear transport. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases, which play a role in various cellular processes, including cell growth and survival. By inhibiting these kinases, wortmannin can indirectly affect the signaling pathways that regulate Ran expression and function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another inhibitor of phosphoinositide 3-kinases. Like wortmannin, it has the potential to disturb the signaling pathways that control the expression and activity of Ran, potentially leading to alterations in nuclear transport and cell cycle progression. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to Hsp90, a chaperone protein involved in the proper folding of various client proteins. By inhibiting Hsp90, geldanamycin can indirectly affect the stability and function of proteins that interact with or regulate Ran, possibly leading to reduced Ran expression. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is an analogue of geldanamycin with improved solubility and reduced toxicity. It also targets Hsp90, potentially affecting the stability and activity of proteins involved in Ran regulation. This could lead to alterations in nuclear transport and cell cycle progression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a kinase involved in cell growth and proliferation. Through its inhibition of mTOR, rapamycin can indirectly affect various signaling pathways and cellular processes, potentially leading to changes in Ran expression and function. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C is a DNA crosslinking agent that can cause DNA damage and inhibit DNA synthesis. By inducing DNA damage, mitomycin C can activate cell cycle checkpoints and potentially lead to alterations in the expression and function of proteins involved in nuclear transport, including Ran. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts and causes DNA damage, leading to the activation of cell cycle checkpoints and alterations in gene expression. These changes can potentially affect the expression and function of proteins involved in nuclear transport, including Ran. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that leads to DNA damage by stabilizing the DNA-topoisomerase I complex. This DNA damage can activate cell cycle checkpoints and potentially affect the expression and function of proteins involved in nuclear transport, including Ran. | ||||||