Rab 24 Activators
Rab24 Activators are a class of compounds that can enhance the functional activity of Rab24, a protein that has a primary role in autophagy and vesicular transport. These compounds do not directly activate Rab24, but rather, they influence the autophagy process and vesicular pathways in which Rab24 is involved, leading to an enhancement of its functional activity. For instance, compounds like Wortmannin, LY294002, and 3-Methyladenine, which are PI3K inhibitors, can enhance Rab24's role in alternative autophagy pathways, thereby promoting its activity. Similarly, compounds like Rapamycin, Torin 1, and PP242, which are mTOR inhibitors known to induce autophagy, can enhance the activity of Rab24, given its involvement in autophagy.
Moreover, compounds like Chloroquine and Verapamil, which affect endosomal acidification and trafficking, can enhance Rab24's role in these processes. On the other hand, compounds like Bafilomycin A1 and Lys05, which inhibit the fusion of autophagosomes and lysosomes and impair lysosomal acidification, respectively, can enhance the role of Rab24 in autophagosome transport and alternative autophagy pathways. Lastly, MG-132, a proteasome inhibitor, can promote autophagy by causing the accumulation of misfolded proteins, thereby enhancing the activity of Rab24 involved in this process. Similarly, Spautin-1, an autophagy inhibitor that targets ubiquitin-specific peptidases, can destabilize Beclin1, thereby enhancing Rab24's role in alternative autophagy pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a covalent inhibitor of PI3K, a kinase involved in autophagy initiation. By inhibiting PI3K, Wortmannin could enhance Rab24's role in alternative autophagy pathways. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is a selective mTOR inhibitor. Since mTOR inhibition is known to induce autophagy, this can enhance Rab24 activity which is involved in autophagic processes. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is an autophagy inhibitor that prevents endosomal acidification. This could enhance Rab24 activity, given its role in endosomal trafficking. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that promotes autophagy. This could enhance Rab24 activity, given its role in autophagic processes. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is an inhibitor of vacuolar H+ ATPase and prevents autophagosome-lysosome fusion. This could enhance the role of Rab24 in autophagosome transport and alternative autophagy pathways. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that can cause the accumulation of misfolded proteins, promoting autophagy. This could enhance Rab24 activity, given its role in autophagy. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
Spautin-1 is an autophagy inhibitor that targets ubiquitin-specific peptidases, leading to the destabilization of Beclin1. This could enhance Rab24 activity in alternative autophagy pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that could enhance Rab24's role in alternative autophagy pathways by inhibiting class I PI3Ks. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
3-Methyladenine is a PI3K inhibitor that suppresses autophagy. By inhibiting class III PI3K, it could enhance Rab24's role in alternative autophagy pathways. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is an ATP-competitive mTOR inhibitor that can induce autophagy, thereby enhancing the activity of Rab24 in autophagic processes. | ||||||