Rab 24 Antibody (43): sc-136049

Rab 24 Antibody (43) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rab 24 protein of mouse, rat, human, and canine origin by western blotting (WB) and immunoprecipitation (IP). Anti-Rab 24 antibody (43) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. Rab 24 is a member of the Ras-related superfamily of guanine nucleotide-binding proteins, which share 30-60% homology with Ras p21. Rab 24 plays a crucial role in the autophagic pathway, a cellular process essential for degrading and recycling cellular components, thereby maintaining cellular homeostasis and responding to stress. Rab 24 helps regulate the transport of proteins and organelles within the cell, ensuring that damaged or unnecessary cellular materials are efficiently removed. Rab 24′s unique characteristics, such as low intrinsic GTPase activity and inefficient prenylation, distinguish Rab 24 from other Rab family members, highlighting specialized functions in cellular transport mechanisms. Anti-Rab 24 antibody (43) enables researchers to gain deeper insights into the dynamics of autophagy and its implications in various physiological and pathological conditions.

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Rab 24 Antibody (43) References:

1. Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells.  |  Erdman, RA., et al. 2000. J Biol Chem. 275: 3848-56. PMID: 10660536
2. Induction of autophagy causes dramatic changes in the subcellular distribution of GFP-Rab24.  |  Munafó, DB. and Colombo, MI. 2002. Traffic. 3: 472-82. PMID: 12047555
3. Mutant Rab24 GTPase is targeted to nuclear inclusions.  |  Maltese, WA., et al. 2002. BMC Cell Biol. 3: 25. PMID: 12323076
4. Tyrosine phosphorylation of the Rab24 GTPase in cultured mammalian cells.  |  Ding, J., et al. 2003. Biochem Biophys Res Commun. 312: 670-5. PMID: 14680817
5. The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach.  |  Chavrier, P., et al. 1992. Gene. 112: 261-4. PMID: 1555775
6. Human RAB24, interestingly and predominantly distributed in the nuclei of COS-7 cells, is colocalized with cyclophilin A and GABARAP.  |  Wu, M., et al. 2006. Int J Mol Med. 17: 749-54. PMID: 16596256
7. The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum.  |  Tambe, Y., et al. 2009. Cancer Lett. 283: 74-83. PMID: 19368996
8. Cryptogenic stroke and underlying atrial fibrillation.  |  Sanna, T., et al. 2014. N Engl J Med. 370: 2478-86. PMID: 24963567
9. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.  |  Zahraoui, A., et al. 1989. J Biol Chem. 264: 12394-401. PMID: 2501306
10. Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy.  |  Tong, M., et al. 2021. Circ Res. 129: 1105-1121. PMID: 34724805
11. Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity.  |  Petersen, MC., et al. 2024. Cell Metab. 36: 745-761.e5. PMID: 38569471
12. Friends and family: the role of the Rab GTPases in vesicular traffic.  |  Novick, P. and Brennwald, P. 1993. Cell. 75: 597-601. PMID: 8242735

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rab 24 Antibody (43) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Rab 24 Antibody (43) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rab 24 Antibody (43) Specifications

Alternate Product Name: Rab 24

Product Clone Name: 43

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 115-203

Epitope Target: Rab 24

Epitope Species: mouse

Product Reactivity/Detection: Rab 24

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Rab 24 Antibody (43): N/A