QPCTL Inhibitors
QPCTL inhibitors belong to a distinctive chemical class primarily associated with the modulation of the enzyme quinolinate phosphoribosyltransferase-like protein (QPCTL). QPCTL, a member of the phosphoribosyltransferase superfamily, plays a crucial role in the quinolinic acid (QA) biosynthetic pathway. This pathway is essential for the de novo synthesis of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme involved in various cellular processes. The QPCTL enzyme catalyzes the conversion of quinolinic acid to nicotinic acid mononucleotide (NAMN), a pivotal step in NAD+ biosynthesis. Inhibition of QPCTL, therefore, has the potential to modulate NAD+ levels within cells.
QPCTL inhibitors are characterized by their ability to selectively interact with the active site of the QPCTL enzyme, disrupting its catalytic function. These inhibitors typically possess a defined pharmacophore that engages specific residues within the enzyme's binding pocket, thereby hindering the conversion of quinolinic acid to NAMN. Understanding the structural determinants of QPCTL inhibition is crucial for the design and development of potent inhibitors with enhanced selectivity and efficacy. Research in this chemical class aims to elucidate the molecular mechanisms governing the interaction between QPCTL inhibitors and the enzyme, providing valuable insights for future drug discovery efforts targeting NAD+ biosynthesis modulation.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor. By inhibiting the proteasome, MG-132 can lead to accumulation of ubiquitinated proteins, indirectly affecting the ubiquitination function of QPCTL. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Proteasome inhibitor. Bortezomib can interfere with ubiquitin-proteasome pathway, which might indirectly influence QPCTL’s protein modification actions. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
Inhibits NEDD8-activating enzyme (NAE). By disrupting NEDD8 modification of cullin proteins, it can alter the ubiquitin ligase activity, potentially affecting QPCTL-mediated ubiquitination processes. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
Ubiquitin-activating enzyme (E1) inhibitor. PYR-41 can prevent the initial step in the ubiquitination cascade, which might indirectly affect QPCTL function. | ||||||
MLN7243 | 1450833-55-2 | sc-507338 | 5 mg | $340.00 | ||
Ubiquitin-activating enzyme (E1) inhibitor. Similar to PYR-41, TAK-243 inhibits the first step of ubiquitination, which can indirectly influence QPCTL function. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Targets cereblon, a component of a ubiquitin ligase complex. By modulating ubiquitin ligase activity, it may indirectly affect QPCTL-mediated ubiquitination processes. | ||||||
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $50.00 $374.00 $2071.00 | 18 | |
Analog of Thalidomide. It also targets cereblon and can influence ubiquitin ligase activity, potentially affecting QPCTL function. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
MDM2 inhibitor. MDM2 is an E3 ubiquitin ligase for p53. By inhibiting MDM2, Nutlin-3 can disrupt ubiquitination of p53, which might indirectly affect the broader ubiquitination landscape and QPCTL function. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
Broad-spectrum deubiquitinating enzyme (DUB) inhibitor. By inhibiting DUBs, PR-619 can lead to accumulation of ubiquitinated substrates, potentially influencing QPCTL's function. | ||||||
NSC697923 | 343351-67-7 | sc-391107 sc-391107A | 1 mg 5 mg | $15.00 $52.00 | 3 | |
Ubc13-Uev1A inhibitor, disrupting the formation of Lys63-linked polyubiquitin chains. This can affect certain ubiquitination processes, potentially influencing QPCTL’s function. | ||||||