QPCTL Antibody (B-3): sc-515717
- QPCTL Antibody (B-3) is a mouse monoclonal IgG2a κ QPCTL antibody provided at 200 µg/ml
- raised against amino acids 276-325 mapping near the C-terminus of QPCTL of human origin
- QPCTL Antibody (B-3) is recommended for detection of QPCTL of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-QPCTL Antibody (B-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for QPCTL Antibody (B-3) for WB applications. These reagents are now offered in bundles with QPCTL Antibody (B-3) (see ordering information below).
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QPCTL Antibody (B-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects QPCTL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-QPCTL antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. QPCTL (B-3) antibody targets glutaminyl-peptide cyclotransferase-like protein, a 382 amino acid single-pass membrane protein that plays a crucial role in the post-translational modification of peptides, specifically in the cyclization of glutaminyl residues. This function influences the bioactivity and stability of neuropeptides and other signaling molecules, thereby impacting various physiological processes such as neurotransmission and immune responses. QPCTL monoclonal antibody (B-3) recognizes a protein encoded by a gene highly conserved across multiple species, including chimpanzees, dogs, cows, mice, rats, zebrafish, and several yeast species, located on human chromosome 19q13.32, a region known for its high gene density and association with various genetic disorders. QPCTL′s ability to bind one zinc ion per subunit further underscores its importance in maintaining structural integrity and enzymatic activity, making QPCTL (B-3) monoclonal antibody an essential tool for researchers studying functional dynamics in different biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
QPCTL Antibody (B-3) References:
- A fine physical map of the CACNA1A gene region on 19p13.1-p13.2 chromosome. | Trettel, F., et al. 2000. Gene. 241: 45-50. PMID: 10607897
- Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). | LaPoint, SF., et al. 2000. Adv Anat Pathol. 7: 307-21. PMID: 10976909
- Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters. | Moodie, SJ., et al. 2002. Eur J Immunogenet. 29: 287-91. PMID: 12121272
- Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2. | Buchet-Poyau, K., et al. 2002. Cytogenet Genome Res. 97: 171-8. PMID: 12438709
- The DNA sequence and biology of human chromosome 19. | Grimwood, J., et al. 2004. Nature. 428: 529-35. PMID: 15057824
- BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription. | Brocke-Heidrich, K., et al. 2006. Oncogene. 25: 7297-304. PMID: 16732314
- A novel CADASIL-causing mutation in a stroke patient. | Vikelis, M., et al. 2007. Swiss Med Wkly. 137: 323-5. PMID: 17629811
- Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors. | Zimmermann, W., et al. 1988. Cancer Res. 48: 2550-4. PMID: 3356015
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
QPCTL Antibody (B-3) | sc-515717 | 200 µg/ml | $322.00 | |||
QPCTL Antibody (B-3): m-IgG Fc BP-HRP Bundle | sc-531480 | 200 µg Ab; 10 µg BP | $361.00 | |||
QPCTL Antibody (B-3): m-IgGκ BP-HRP Bundle | sc-525177 | 200 µg Ab, 40 µg BP | $361.00 | |||
QPCTL Antibody (B-3): m-IgG2a BP-HRP Bundle | sc-547799 | 200 µg Ab; 10 µg BP | $361.00 | |||
QPCTL Antibody (B-3) AC | sc-515717 AC | 500 µg/ml, 25% agarose | $424.00 | |||
QPCTL Antibody (B-3) HRP | sc-515717 HRP | 200 µg/ml | $322.00 | |||
QPCTL Antibody (B-3) FITC | sc-515717 FITC | 200 µg/ml | $336.00 | |||
QPCTL Antibody (B-3) PE | sc-515717 PE | 200 µg/ml | $349.00 | |||
QPCTL Antibody (B-3) Alexa Fluor® 488 | sc-515717 AF488 | 200 µg/ml | $364.00 | |||
QPCTL Antibody (B-3) Alexa Fluor® 546 | sc-515717 AF546 | 200 µg/ml | $364.00 | |||
QPCTL Antibody (B-3) Alexa Fluor® 594 | sc-515717 AF594 | 200 µg/ml | $364.00 | |||
QPCTL Antibody (B-3) Alexa Fluor® 647 | sc-515717 AF647 | 200 µg/ml | $364.00 | |||
QPCTL Antibody (B-3) Alexa Fluor® 680 | sc-515717 AF680 | 200 µg/ml | $364.00 | |||
QPCTL Antibody (B-3) Alexa Fluor® 790 | sc-515717 AF790 | 200 µg/ml | $364.00 |