Date published: 2026-4-1

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PRAME like-4 Inhibitors

PRAME-like 4 inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of the PRAME-like 4 protein, a member of the PRAME (Preferentially Expressed Antigen in Melanoma) family of proteins. The PRAME family is known to be involved in various cellular processes, particularly those related to gene regulation. PRAME-like 4 is thought to play a role in transcriptional repression, likely through interactions with other regulatory proteins or transcription factors. By binding to these regulatory components, PRAME-like 4 may modulate gene expression patterns that are crucial for maintaining cellular function. Inhibitors of PRAME-like 4 function by blocking its ability to interact with these transcriptional complexes, thereby altering its role in gene regulation.

Using PRAME-like 4 inhibitors in research helps scientists investigate the specific molecular mechanisms underlying its role in transcriptional regulation. These inhibitors allow researchers to explore how the disruption of PRAME-like 4 activity impacts cellular gene expression profiles, shedding light on its contributions to broader regulatory networks. By inhibiting PRAME-like 4, scientists can examine changes in protein interactions, chromatin remodeling, and overall transcriptional control within the cell. Additionally, studying these inhibitors provides insights into how PRAME-like 4 fits into the complex network of proteins that regulate gene expression, offering a deeper understanding of its role in maintaining cellular homeostasis and responding to environmental signals. This research ultimately helps unravel the precise functions of PRAME-like 4 in cellular processes such as differentiation, proliferation, and signaling.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

This agent may cause hypomethylation of the PRAME like-4 promoter region, consequently increasing gene transcription, thereby potentially increasing PRAME like-4 expression.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$133.00
$275.00
37
(2)

Suberoylanilide Hydroxamic Acid potentially leads to hyperacetylation of histones associated with the PRAME like-4 gene locus, which could loosen chromatin structure and inadvertently promote gene expression.

Disulfiram

97-77-8sc-205654
sc-205654A
50 g
100 g
$53.00
$89.00
7
(1)

Disulfiram might inhibit aldehyde dehydrogenase, which could create a cellular state that inadvertently increases PRAME like-4 gene transcription.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$218.00
$322.00
$426.00
7
(1)

Similar to 5-Azacytidine, 5-Aza-2′-Deoxycytidine may decrease methylation at the PRAME like-4 gene promoter, potentially resulting in higher levels of transcription.

Mithramycin A

18378-89-7sc-200909
1 mg
$55.00
6
(1)

By binding to DNA, Mithramycin A might block the binding sites for transcription factors that control the PRAME like-4 gene, which could unintentionally enhance its transcription.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic Acid could activate retinoic acid receptors that bind to the PRAME like-4 promoter region, potentially promoting transcription of the gene.

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$90.00
$204.00
13
(1)

Triptolide may inhibit the transcription of several genes, including PRAME like-4, which could lead to a decrease in its mRNA and protein levels.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin might interfere with specific transcription factor pathways that are involved in the transcriptional activation of the PRAME like-4 gene, inadvertently amplifying its expression.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol could activate sirtuins that indirectly lead to the transcriptional enhancement of the PRAME like-4 gene.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$31.00
$47.00
$84.00
$222.00
19
(3)

Sodium Butyrate may cause hyperacetylation of histones at the PRAME like-4 gene locus, potentially increasing the transcriptional activity of the gene.