PPP4R4 Inhibitors
PPP4R4 inhibitors function by indirectly influencing the biochemical pathways that this regulatory protein is involved in, particularly those related to dephosphorylation events within the cell. These chemical compounds achieve their inhibitory effects by targeting protein phosphatases like PP1, PP2A, and PP2B, which are enzymes whose activities are closely overseen by PPP4R4. Inhibitors that thwart these phosphatases can disrupt the delicate equilibrium of phosphorylation and dephosphorylation that PPP4R4 helps to maintain, resulting in an indirect impediment of PPP4R4's function. The disruption of this equilibrium can lead to aberrant regulation of substrates that PPP4R4 typically regulates, thereby hindering its regulatory function. Some inhibitors act by selectively targeting PP2A and PP4, which may affect PPP4R4 by altering substrate dephosphorylation processes that are part of PPP4R4's repertoire. The precise modulation of phosphatase activity by these inhibitors leads to modifications in the signaling pathways where PPP4R4 plays a regulatory role, thereby indirectly inhibiting PPP4R4's activity.
In addition to their effects on protein phosphatases, some PPP4R4 inhibitors also exert influence over other related signaling pathways, potentially affecting the protein's role in these processes. For example, certain compounds that inhibit fatty acid synthase cause changes in cellular lipid composition, which can have downstream effects on membrane-associated signaling events where PPP4R4 is implicated. This alteration in lipid composition can affect the localization, interaction, or activity of PPP4R4 within cellular membranes. Moreover, inhibitors of the PI3K pathway can impact PPP4R4 indirectly by influencing downstream signaling pathways that regulate the phosphorylation status of proteins, including those within the operational purview of PPP4R4.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). Can indirectly impact the activity of PPP4R4 by altering the balance of phosphatase activities in the cell, leading to dysregulation of dephosphorylation processes which PPP4R4 is involved in. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Inhibits PP2A and potentially affects PPP4R4 function by disrupting the overall phosphatase activity within cells, which could lead to an aberrant regulation of substrates shared with PPP4R4. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
As an inhibitor of PP1 and PP2A, this compound could interfere with PPP4R4 by disrupting the phosphatase activity balance, and thereby indirectly altering PPP4R4's regulatory actions in dephosphorylation pathways. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Inhibits calcineurin (PP2B), which might disrupt signaling pathways that intersect with PPP4R4's regulatory functions, affecting its role in dephosphorylation events. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $48.00 $199.00 | 1 | |
Acting as an inhibitor of PP2A, this compound may influence PPP4R4 indirectly by perturbing the phosphatase activity and thus modifying the signaling pathways where PPP4R4 plays a regulatory role. | ||||||
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $260.00 | 9 | |
Selectively inhibits PP2A and PP4, which could indirectly influence PPP4R4 function by modifying the substrate dephosphorylation processes that PPP4R4 is associated with. | ||||||
Phenothiazine | 92-84-2 | sc-250686 sc-250686A | 50 g 250 g | $23.00 $43.00 | ||
With PP2A inhibitory activity, this compound may indirectly affect PPP4R4 by altering dephosphorylation signaling processes in which PPP4R4 is implicated. | ||||||
LB-100 | 1632032-53-1 | sc-507368 | 10 mg | $330.00 | ||
A small-molecule inhibitor of PP2A, it could indirectly influence PPP4R4 by impacting the phosphatase-dependent signaling networks, potentially altering PPP4R4's role in these networks. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $158.00 $306.00 $1186.00 | 9 | |
By inhibiting fatty acid synthase, this compound leads to an alteration in cellular lipid composition, which could indirectly influence the membrane-associated signaling events where PPP4R4 is involved. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
An inhibitor of PI3K, this compound might impact PPP4R4 indirectly by influencing downstream signaling pathways that affect the phosphorylation status of proteins regulated by phosphatases, including PPP4R4. | ||||||