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Phenothiazine (CAS 92-84-2)

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Alternate Names:
Thiodiphenylamine; 10H-Phenothiazine; PTZ
Application:
Phenothiazine is a rigid, tricyclic thiazine useful as an electron donor
CAS Number:
92-84-2
Purity:
≥98%
Molecular Weight:
199.27
Molecular Formula:
C12H9NS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Phenothiazine is a heterocyclic compound that is extensively studied in various research areas, including organic chemistry and materials science. It is frequently used as a building block for synthesizing a wide array of dyes and chemicals. In electrochemistry, phenothiazine is of interest due to its redox properties, which are leveraged to study electron transfer processes and the development of organic electronic devices such as organic light-emitting diodes (OLEDs) and solar cells. Additionally, its function as a photostabilizer is examined, particularly in the stabilization of polymers against UV light degradation. In the field of catalysis, phenothiazine derivatives are explored for their potential to act as ligands or catalysts in chemical reactions to enhance selectivity and yield.


Phenothiazine (CAS 92-84-2) References

  1. Oxidation of phenothiazine and phenoxazine by Cunninghamella elegans.  |  Sutherland, JB., et al. 2001. Xenobiotica. 31: 799-809. PMID: 11765142
  2. Novel phenothiazine antimalarials: synthesis, antimalarial activity, and inhibition of the formation of beta-haematin.  |  Kalkanidis, M., et al. 2002. Biochem Pharmacol. 63: 833-42. PMID: 11911834
  3. [Alcohol potentiation by phenothiazine].  |  KOPF, R. 1957. Arch Int Pharmacodyn Ther. 110: 56-64. PMID: 13425746
  4. The psychopharmacology of phenothiazine compounds: a comparative study of the effects of chlorpromazine, promethazine, trifluoperazine and perphenazine in normal males. I. Introduction, aims and methods.  |  DIMASCIO, A., et al. 1963. J Nerv Ment Dis. 136: 15-28. PMID: 14027912
  5. THE EFFECT OF SOME PHENOTHIAZINE TRANQUILLIZERS ON THE OESTROUS CYCLE OF ALBINO MICE.  |  BHARGAVA, KP. and JAITLY, KD. 1964. Br J Pharmacol Chemother. 22: 162-5. PMID: 14126046
  6. Phenothiazine-based oligomers as novel fluorescence probes for detecting vapor-phase nitro compounds.  |  Zhang, X., et al. 2010. Talanta. 82: 1943-9. PMID: 20875600
  7. Phenothiazine: the seven lives of pharmacology's first lead structure.  |  Ohlow, MJ. and Moosmann, B. 2011. Drug Discov Today. 16: 119-31. PMID: 21237283
  8. Phenothiazine-sensitized organic solar cells: effect of dye anchor group positioning on the cell performance.  |  Hart, AS., et al. 2012. ACS Appl Mater Interfaces. 4: 5813-20. PMID: 23043502
  9. Peptide chemistry applied to a new family of phenothiazine-containing inhibitors of human farnesyltransferase.  |  Dumitriu, GM., et al. 2014. Bioorg Med Chem Lett. 24: 3180-5. PMID: 24856060
  10. Design of new phenothiazine-thiadiazole hybrids via molecular hybridization approach for the development of potent antitubercular agents.  |  Ramprasad, J., et al. 2015. Eur J Med Chem. 106: 75-84. PMID: 26520841
  11. Design, synthesis and evaluation of novel phenothiazine derivatives as inhibitors of breast cancer stem cells.  |  Gao, Y., et al. 2019. Eur J Med Chem. 183: 111692. PMID: 31541872
  12. The role of phenothiazine derivatives in autophagy regulation: A systematic review.  |  Otręba, M., et al. 2023. J Appl Toxicol. 43: 474-489. PMID: 36165981
  13. Phenothiazine-associated supraventricular tachycardia.  |  Durst, R., et al. 1994. Aust N Z J Psychiatry. 28: 333-6. PMID: 7993292
  14. [Phenothiazine drugs as photosensitizers and photoprotectors].  |  Makareeva, EN., et al. 1998. Biofizika. 43: 181-5. PMID: 9591093

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Phenothiazine, 50 g

sc-250686
50 g
$23.00

Phenothiazine, 250 g

sc-250686A
250 g
$43.00